Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-05-29
2007-05-29
Morris, Patricia L. (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C546S275400, C546S276100
Reexamination Certificate
active
10116135
ABSTRACT:
The invention discloses a new clause of a five membered heterocylic ring compounds of general formula Iand its pharmaceutically or cosmetically acceptable salts, wherein R1, R2, R3, R4, R5, A, B, X and Y are as defined in the specification. The invention also discloses a process for preparation of these compound and their therapeutic and cosmetic applications particularly in the management of aging related and diabetic vascular complications. The compounds in question act by triple action of an AGE (Advanced Glycation Endproducts) breaker, AGE inhibitor and free radical scavenger which make them most suitable in different therapeutic and cosmetic applications. The invention also discloses pharmaceuticals and cosmetic compositions comprising these compounds and method of treatment of diseases caused by accumulation of AGE and/or free radicals in the body cells.
REFERENCES:
patent: 4758583 (1988-07-01), Cerami et al.
patent: 5137916 (1992-08-01), Ulrich et al.
patent: 5272176 (1993-12-01), Ulrich et al.
patent: 5514676 (1996-05-01), Ulrich et al.
patent: 5656261 (1997-08-01), Cerami et al.
patent: 5853703 (1998-12-01), Cerami et al.
patent: 2001/0025056 (2001-09-01), Maignan
patent: 0339496 (1989-11-01), None
patent: 0 563 686 (1993-10-01), None
patent: 1068864 (2001-01-01), None
patent: 1110539 (2001-06-01), None
patent: WO 00/66101 (2000-11-01), None
patent: WO 01/25208 (2001-04-01), None
patent: WO 01/25209 (2001-04-01), None
Ferles et al, “Studies in the pyridine , etc” CA 96: 104035 (1982).
Brownlee M et al. Science, 1986, 232: 1629-1632.
Vasan et al., Nature 1996; 382: 275-278.
Beisswenger P. J et al., Diabetes vol. 11, Jul. ; 824-829.
Makita et al., The New England Journal of Medicine, vol. 325 No. 12, Sep. 19, 1991, 836-842.
Yamauchi A et al., diabetes Res Clin Pract Jan. 1997 34(3) : 127-33 (Abstract).
Ellis E N et al., Metabolism Oct. 1991; 40(10): 1016-1019(Abstract).
Soulis Liparoto et al., Diabetes 40: 1328-34, 1991.
Hirata C et al., Biochem Biophys Res Commun Jul. 30, 1997: 236(3); 712-715.
Murata et al., Diabetologia Jul. 1997; 40(7) : 764-769.
Hammes et al. Proc. Natl. Acad Sci USA, vol. 88 pp. 11555-11558, Dec. 1991, Medical Sciences.
Roufail E. Diabetologia Dec. 1998; 41 (12): 1419-1425.
Kihara Mikihiro et al. Proc. Natl. Acad. Sci. U.S.A, vol. 88, pp. 6107-6111, Jul. 1991, Medical Sciences.
Miyauchi Y et al, Eur J Endocrinol Apr. 1996: 134(4): 467-73(Abstract).
Yagihashi Soroku et al. Diabetes vol. 41, Jan. 1992, 47-52.
Bucala R, Diabetes Res Clin Pract Feb. 1996: 30 Suppl: 123-30(Abstract).
Kirstein. M et al, Proc. Natl. Acad. Sci. U.S.A vol. 87, pp. 9010-9014 Nov. 1990, Medical Sciences.
Wolffenbuttel Bruce H R et al., Proc. Natl. Acad. Sci. USA, vol. 95, pp. 4630-4634, Apr. 1998, Medical Sciences.
Aronson D et al., J Am Coll Cardiol Mar. 1, 1996; 27(3): 528-35, (Abstract).
Seftel AD, Urology, Dec. 1997: 50(6): 1016-26.
Michael P. Vitek et al., Proc. Natl. Acad, Sci USA, vol. 91, pp. 4766-4770, May 1994 Neurobiology.
Yong Ming Li et al., Proc. Natl. Acad. Sci. USA, vol. 93,pp. 3902-3907, Apr. 1996, Medical Sciences.
Hakon Nordbo, J Dent Res 58(4): 1429, Apr. 1979, (Abstract).
Boni R, et al. Schweiz Med Wochenschr(2000), Sep. 9; 130(36) : 1272-8 (Abstract).
Odetti P et al., Gerontology(1998) ; 44(4) : 187-91(Abstract).
Pugliese PT,Dermatol Nurs Dec. 1998 10(6) : 401-16; 187-91quiz 417-18 (Abstract).
Calabrese V et al., Drugs Exp Clin. Res X X V (6) 281-287 (1999).
Berneburg M et al., Photodermatol photoimmunol Photomed (2000) Dec. ; 16(6) ; 239-44 (Abstract).
Masaki H, Biochem Biophys Res Commun Jun. 18, 1997, 235(2): 306-10 (Abstract).
Hitoshi Masaki et. al., Biochemia et Biophysica Acta 1428 (1999) 45-56.
G. Muinch et al., J Neural Transm (1998) 105 : 439-461.
Smith M A et al., Biochim Biophys Acta Jul. 26, 2000; 1502(1):139-44, (Abstract).
Browne S.E et al., Brain Pathology 9 : 147-163 (1999).
E.J Harper, The 24thannual Waltham / OSU symposium, (2000).
Dario Giugliano et al., Diabetes Care, vol. 19, No. 3, Mar. 1996, 257-267.
Ishii Hiromasa et al., Journal of Gastroenterology and Hepatology (1997) 12 (Suppl.), S272-S282.
G. Zalba et al., J Physiol Biochem, 56 (1), 57-64, 2000.
Crawford R.S et al., Arterioscler Thromb Vasc Biol Sep. 1998;18 (9): 1506-13, (Abstract).
Maxwell et al., Br j Clin Pharmacol 1997 :44: 307-317.
MacNee W et al., Trends Mol Med Feb. 2001; 7(2): 55-62(Abstract).
Brownlee, Annu. Review Med. , 223-233(1995).
C. Jeanmaire et al., British Journal of Dermatology 2001 : 145: 10-18.
Hammes H P et al. , Diabetologia Jan. 1994 ; 37(1):32-35.
Tupper, D. E. et al.: “The synthesis and Reaction of 4-(2-and3-Thienyl)-tetrahydroisoquinolines” J. Heterocyclic Chem, vol. 33, No. 4, 1996, pp. 1123-1129.
Westphal, O. et al.; “Synthesis of New Thiazolo -[3,2-α] pyridinium Salts” Angew.Chem., vol. 8, No. 1, 1969, p. 74.
Morris Patricia L.
Torrent Pharmaceuticals Ltd.
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