Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1998-06-10
2000-09-05
Yucel, Remy
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 4, 435 71, 435 72, 435 29, G01N 33567
Patent
active
061141267
ABSTRACT:
Compounds which can stimulate neuronal growth by inhibiting the neuronal inhibitory activity of myelin-associated glycoprotein (MAG), and a method of using the compounds for stimulating neuronal growth are provided. The invention further provides a method of identifying compounds which inhibit myelin-associated glycoprotein inhibition of axonal outgrowth of injured nerve cells. The method involves contacting the compound with myelin-associated glycoprotein under conditions which allow myelin-associated glycoprotein and the compound to bind and detecting the binding.
REFERENCES:
Yang, et al. Gangliosides are Neuronal Ligands for Myelin-associated Glycoprotein, Proc. Natl. Acad. Sci., 93:814-818, Jan. 1996.
Wietholter, H., et al., Influence of Gangliosides on Experimental Allergic Neuritis, Journal of Neuroimmunology, 38:221-228, 1992.
Nakajima, et al., Bioactive Gangliosides: Analysis of Functional Structures of the Tetrasialoganglioside G.sub.Q1b Which Promotes Neurite Outgrowth, 876:65-71, 1986.
Matta, et al., Neuritogenic and Metabolic Effects of Individual Gangliosides and their Interaction with Nerve Growth Factor in Cultures of Neuroblastoma and Pheochromocytoma, Developmental Brain Research, 27:243-252, 1986.
Hasegawa Akira
Schnaar Ronald L.
Yang Lynda J. S.
The Johns Hopkins University
Yucel Remy
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