Compounds for stimulating nerve growth

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514 25, 435 71, 536 53, 536 551, A61K 31715, C07H 504

Patent

active

059624345

ABSTRACT:
Compounds which can stimulate neuronal growth by inhibiting the neuronal inhibitory activity of myelin-associated glycoprotein (MAG), and a method of using the compounds for stimulating neuronal growth are provided. The invention further provides a method of identifying compounds which inhibit myelin-associated glycoprotein inhibition of axonal outgrowth of injured nerve cells. The method involves contacting the compound with myelin-associated glycoprotein under conditions which allow myelin-associated glycoprotein and the compound to bind and detecting the binding.

REFERENCES:
Hirabayashi et al. The Journal of Biological Chemistry Jun. 25, 1992, 267(18), 12973-12978.
Munesada et al. J. Chem. Soc. Perkin Trans. I 1989, 1491-1496, month not available.
Yang, et al. Gangliosides are Neuronal Ligands for Myelin-associated Glycoprotein, Proc. Natl. Acad. Sci., 93:814-818, Jan. 1996.
Wietholter, H., et al., Influence of Gangliosides on Experimental Allergic Neuritis, Journal of Neuroimmunology, 38:221-228, 1992.
Nakajima, et al., Bioactive Gangliosides: Analysis of Functional Structures of the Tetrasialoganglioside G.sub.Q1b Which Promotes Neurite Outgrowth, 876:65-71, 1986.
Matta, et al., Neuritogenic and Metabolic Effects of Individual Gangliosides and their Interaction with Nerve Growth Factor in Cultures of Neuroblastoma and Pheochromocytoma, Developmental Brain Research, 27:243-252, 1986, no month available.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Compounds for stimulating nerve growth does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Compounds for stimulating nerve growth, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compounds for stimulating nerve growth will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1171538

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.