Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1996-08-23
1999-10-05
Fonda, Kathleen K.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514 25, 435 71, 536 53, 536 551, A61K 31715, C07H 504
Patent
active
059624345
ABSTRACT:
Compounds which can stimulate neuronal growth by inhibiting the neuronal inhibitory activity of myelin-associated glycoprotein (MAG), and a method of using the compounds for stimulating neuronal growth are provided. The invention further provides a method of identifying compounds which inhibit myelin-associated glycoprotein inhibition of axonal outgrowth of injured nerve cells. The method involves contacting the compound with myelin-associated glycoprotein under conditions which allow myelin-associated glycoprotein and the compound to bind and detecting the binding.
REFERENCES:
Hirabayashi et al. The Journal of Biological Chemistry Jun. 25, 1992, 267(18), 12973-12978.
Munesada et al. J. Chem. Soc. Perkin Trans. I 1989, 1491-1496, month not available.
Yang, et al. Gangliosides are Neuronal Ligands for Myelin-associated Glycoprotein, Proc. Natl. Acad. Sci., 93:814-818, Jan. 1996.
Wietholter, H., et al., Influence of Gangliosides on Experimental Allergic Neuritis, Journal of Neuroimmunology, 38:221-228, 1992.
Nakajima, et al., Bioactive Gangliosides: Analysis of Functional Structures of the Tetrasialoganglioside G.sub.Q1b Which Promotes Neurite Outgrowth, 876:65-71, 1986.
Matta, et al., Neuritogenic and Metabolic Effects of Individual Gangliosides and their Interaction with Nerve Growth Factor in Cultures of Neuroblastoma and Pheochromocytoma, Developmental Brain Research, 27:243-252, 1986, no month available.
Hasegawa Akira
Schnaar Ronald L.
Yang Lynda J. S.
Fonda Kathleen K.
The Johns Hopkins University School of Medicine
LandOfFree
Compounds for stimulating nerve growth does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compounds for stimulating nerve growth, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compounds for stimulating nerve growth will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1171538