Compounds for preparing 6-phenyl-2,3-dihydroimidazo[2,1-b]-thiaz

Details Compounds for preparing 6-phenyl-2,3-dihydroimidazo[2,1-b]-thiaz Compounds for preparing 6-phenyl-2,3-dihydroimidazo[2,1-b]-thiaz

1988-11-03

1991-04-16

Fan, Jane T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

544 48, 548154, 548155, C07D51304

Patent

active

050083902

ABSTRACT:
6-Aryl-2,3-dihydroimidazo[2,1-b]thiazoles and corresponding thiazines act as nucleophiles, either directly or in the form of Grignard reagents, with N-acylpyridinium salts to produce new 6-aryl-5-(N-acyl-1,4-dihydro-4-pyridyl)-2,3-dihydroimidazo-[2,1-b]thiazole s and corresponding thiazines. These are oxidized to give the corresponding pyridyl-substituted imidazo[2,1-b]thiazoles and thiazines, which are active as inhibitors of the 5-lipoxygenase pathway of arachidonic acid metabolism.

REFERENCES:
patent: 4175127 (1979-11-01), Bender et al.
D. L. Comins, Tetrahedron Letters 24 (1983).
K. Akiba et al., Tetrahedron Letters 23, 429 (1982).
D. L. Comins et al., J. Org. Chem. 47, 4315 (1982).
Chemical Abstracts, vol. 78, No. 25, pp. 418-419, 159620j (1973).

Affiliated with

Also associated with

Rating

Compounds for preparing 6-phenyl-2,3-dihydroimidazo[2,1-b]-thiaz does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Compounds for preparing 6-phenyl-2,3-dihydroimidazo[2,1-b]-thiaz, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compounds for preparing 6-phenyl-2,3-dihydroimidazo[2,1-b]-thiaz will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-422192