Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Reexamination Certificate
2011-03-15
2011-03-15
Crane, Lawrence E (Department: 1623)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
C536S026130
Reexamination Certificate
active
07906491
ABSTRACT:
The present invention relates to novel compounds for modulating the activity of exchange proteins directly activated by cAMP (Epacs). In particular, the present invention relates to cAMP analogues that specifically modulate the activity of Epacs. Examples of the compounds of the invention are substituted deoxyadenosine-cyclic monosphosphates.The invention further relates to pharmaceutical compositions comprising the novel compounds, and the use of the compounds in the treatment of diseases like cancer, chronic inflammation, thrombosis and/or type-2 diabetes mellitus in humans and/or animals.
REFERENCES:
patent: 3712885 (1973-01-01), Weimann et al.
patent: 5559102 (1996-09-01), Yano et al.
patent: 2233692 (1990-09-01), None
patent: 2258797 (1990-10-01), None
patent: 3072493 (1991-03-01), None
patent: 9295915 (1997-11-01), None
patent: 11-130792 (1999-05-01), None
patent: 11130792 (1999-05-01), None
patent: 3773148 (2006-05-01), None
Schwede et al., “8-Substituted cAMP Analogues Reveal Marked Differences in Adaptability, Hydrogen Bonding, and Charge Accommodation between Homologous Binding Sites (AI/AII and BI/BII) in cAMP Kinase I and II,” Biochemistry, 39(30), 8803-8812 (Jul. 7, 2000).
Enserink et al., “A Novel Epac-specific cAMP Analogue Demonstrates Independent Regulation of Rap1 and ERK,” Nature Cell Biology, 4(11), 901-906 (Oct. 28, 2002).
Peters et al., “Selective Induction of Gene Expression and Second-messenger Accumulation in Dictyostelium discoideum by the Partial Chemotactic Antagonist 8-p-chlorophenylthioadenosine 3′,5′-cyclic Monophosphate,” Proc. nat. Acad, Sci USA, 88, 9219-9223 (Oct. 1991).
Sopchik et al., “Conformations of the Phosphorus-containing Rings of Nucleoside Cyclic 3′,5′-Phosphoramidates. The Questions of the Chair or Twist Free Energy Change for cAMP,” Journal of Organic Chemistry, 56(20), 5911-5918 (Sep. 1991).
Kataoka et al., “Studies on the Synthesis of Compounds Related to Adenosine-3′,5′-Cyclic Phosphate. VI. Synthesis and Cardiac Effects of N6, N6,2′-O-trialkyl-, N6, 2′-O-dialkyl-, and 2′-O-Alkyladenosine-3′,5′-Cyclic Phosphate,” Chem. & Pharmaceutical Bull. (Japan), 38(6), 1596-1600 (1990).
Ikehara, M., “2′-Substituted 2′-Deoxypurinenucleotides, Their Conformation, and Properties,” Heterocycles, 21(1), 75-90 (1984).
Gulyaev et al., “Synthesis of 2′-substituted Derivatives of 8-Hydroxyadenosine 3′,5′-Cyclic Phosphate,” Bioorganischeskaya Khimiya, 7(4), 552-558 (1981); only Abstract provided.
Broeders et al. “A31P NMR Stereochemical and Kinetic Study of the Alkaline Hydrolysis ofcis-Nucleoside 3′,5′-Cyclic Aryl [180]Monophosphates and Unlabled Analogs”,Amer Chem Society(1992), vol. 114, No. 24, pp. 9624-9633.
Ichiba et al. “Characterization of GFR, a novel guanine nucleotide exchange factor for Rap1”FEBS Letters(1999) vol. 457:85-89.
McPhee et al. “Use of an activiation-specific probe to show that Rap1A and Rap1B display different sensitivities to activation for forskolin in Rat1 cells”FEBS Letters(2000) vol. 477: 213-218.
Rooij et al. “Epac is a Rap 1 quanine-nucleotide-exchange factor directly activated by cyclic AMP”Nature(1998) vol. 396: 474-477.
Uesugi, S. et al., “Carbon-13 NMR spectrum of 2′-fluoro-2′-deoxyadenosine 3′,5′-cyclic phosphate”Heterycycles, (1982) vol. 17, issue 1, pp. 285-288 (previously cited as: C6: Caesar accession No. 1796, AN: 96:143250 CA).
Bos Johannes
Christensen Anne
De Koning John
Doskeland Stein
Genieser Hans Gottfired
Crane Lawrence E
Morgan & Lewis & Bockius, LLP
Trecartin Richard F.
Univisitair Medisch Centrum Utrecht
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