Compounds for inhibiting KSP kinesin activity

Details Compounds for inhibiting KSP kinesin activity Compounds for inhibiting KSP kinesin activity

2006-03-07

2009-10-27

Marschel, Ardin (Department: 1614)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ketone doai

C544S279000, C544S284000, C514S292000, C514S260100, C514S264100, C514S265100, C514S290000, C546S083000

Reexamination Certificate

active

07608643

ABSTRACT:
The present invention relates to compounds of Formula I or pharmaceutically acceptable salts or solvates thereof:The present invention provides compositions comprising these compounds that are useful for treating cellular proliferative diseases or disorders associated with KSP kinesin activity and for inhibiting KSP kinesin activity.

REFERENCES:
patent: 26 38 828 (1978-03-01), None
patent: WO 02/28837 (2002-04-01), None
patent: WO 03/040096 (2003-05-01), None
patent: WO 03/050064 (2003-06-01), None
patent: WO 03/055878 (2003-07-01), None
patent: WO 2004/022523 (2004-03-01), None
patent: WO 2004/111058 (2004-12-01), None
Morissette et al, High-throughput cyrstallization: polymorphs, salts, co-crystals and solvates of pharmeceutical solids, Advance drug delivery Reviews 56 (2004) 275-300.
Vippagunta et al, Crystalline solids, Advanced Drug Delivery Reviews vol. 48, Issue 1, May 16, 2001, pp. 3-26.
Cox, et al.: Kinesin spindle protein (KSP) Inhibitors. Part 1: “The discovery of 3,5-diaryl-4,5-dihydropyrazoles as potent and selective inhibitors of the mitotic kinesin KSP” Bioorganic & Medicinal Chemistry Letters, 2005, vol. 15, pp. 2041-2045.
Dabaeva et al.: “Synthesis of dihydro-10H-pyrano[3′,4′:5,6]pyrido[3,2:4″,5″]-thieno[3″,2″-d][3,1]oxazines and pyrimidines”, Chemistry of Heterocyclic Compounds (1995), pp. 219-222, vol. 31, No. 2. XP009069920.
Dotsenko et al.: Synthesis of condenses sulfur-containing heterocycles based on partly hydrogenated pyridines. Database CAPLUS [online] Chemical Abstracts Service, Columbus, Ohio (2004), 3 pgs. XP002392884.
El-Dean et al.: “Synthesis of Some Thienotetrahydroquinoline Derivatives”, Journal of the Chinese Chemical Society (2004), pp. 335-345, vol. 51, No. 2. XP009069921.
Fathy, N.M. et al.: “Synthesis of some thienoquinoline derivatives with expected pharmacological activity.” Egyptian Journal of Pharmaceutical Sciences, 1990, vol. 31, pp. 375-383 (abstract only).
Federov et al.; “Reactions of (S)-N-trifluoroacetyl-5-bromo-4-oxonorvaline methyl ester with vicinal mercaptonitriles. Synthesis of delta-hetaryl-substituted alpha-amino acids” Russian Chemical Bulletin (2003), pp. 2063-2069, vol. 52, No. 9. XP002392838.
Gnanasekaran et al.: “Thienoquinolines; Part VIII. A three-step synthesis of thieno[2,3-b]quinolines from anilines”, Synthesis (1977), pp. 612-614, vol. 9. XP002387124.
Hull, Roy: “Reactions of heterocycles with thiophosgene. Part II. Then chemistry of 3-formylquinoline-2(1H)-thione” Journal of the Chemical Society, Perkin Transactions 1 (1973), pp. 2911-2914, vol. 23. XP008065720.
Ibrahim et al.: “Intramolecular 4+2 cycloaddition of thieno[2,3-e][1,2,4]triazines: routes towards condensed thieno[2,3-b]pyridines”. Tetrahedron (Oct. 20, 2003), pp. 8489-8498, vol. 59, No. 43. XP004463728.
Kim, et al.: Synthesis and SAR of pyrrolotriazine-4-one based Eg5 inhibitors. Bioorganic & Medicinal Chemistry Letters, 2006, vol. 16, pp. 3937-3942.
Klemm et al.: “Chemistry of thienopyridines. XXXVII. Syntheses in the Cyclopenta, Cyclohexa-, and cycloheptathieno[2,3-b]pyridine Series. Three analogs of 9-amino-1,2,3,4-tetrahydroacridine [1]”, Journal of Heterocyclic Chemistry (1990), pp. 1537-1541, vol. 27, No. 6. XP002392839.
Meth-Cohn, Otto: “A versatile new synthesis of quinolines and related fused pyridines. Part 9. Synthetic application of the 2-chloroquinoline-3-carboxaldehydes.” Journal of the Chemical Society, Perkin, Transactions 1 1981, pp. 2509-2517 (abstract only).
Nithyadevi, V. et al: “Synthesis of thieno(2,3-b)quinoline-2-carboxylic esters from 3-(2-oxo-1,2-dihydro-3-quinolyl)acrylic esters.” Heterocyclic Communications, 2004, vol. 10, pp. 339-342 (abstract).
Nithyadevi, V. et al: “Synthesis and spectral studies of thieno(2,3-b)quinoline derivatives”, Asian Journal of Chemistry 2004, vol. 16, pp. 3-4 XP008065724.
Rodinovskaya et al.: “Regioselective synthesis of 5,6-polymethylene-3-cyanopyridine-2(1H)-thiones and fused heterocycles based on them”:, Russian Chemical Bulletin (1994), pp. 449-457, vol. 43, No. 3. XP009069913.
Rodinovskaya et al.: “Synthesis of substituted 4-hydroxy-1H-thieno[2,3-b;4,5-b′]dipyridin-2-ones”: Russian Chemical Bulletin (2000), pp. 348-354, vol. 49, No. 2. XP009070162.
Sunder-Plassman, et al.: “Synthesis and biological evaluation of new tetrahydro-b-carbolines as inhibitors of the mitotic kinesin Eg5”, Bioorganic & Medicinal Chemistry 2005, pp. 6094-6111.
Suzuki et al.: “Synthesis of Antimicrobial Agents.III. Synthesis and Antimicrobial Activities of Thiazolo[5,4-b]naphthyridine Derivatives”, Chem. Pharm. Bull. (1979), pp. 410-418, vol. 27, No. 2. XP001247411.
Tarby , et al.: “Inhibitors of human mitotic kinesin Eg5: characterization of the 4-phenyl-tetrahydroisoquinoline lead series”, Bioorganic & Medicinal Chemistry Letters 2006, vol. 16, pp. 2095-2100.
International Search Report for International Application No. PCT/US2006/008150, mailed Jul. 12, 2006—5pgs.
International Search Report for International Application No. PCT/US2006/008145, mailed Sep. 28, 2006-13 6pgs.

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