Compounds for hedgehog pathway blockade in proliferative...

Details Compounds for hedgehog pathway blockade in proliferative... Compounds for hedgehog pathway blockade in proliferative...

2011-01-11

2011-01-11

Huff, Sheela J (Department: 1643)

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

C514S504000

Reexamination Certificate

active

07867492

ABSTRACT:
Elevated Hedgehog (Hh) pathway activity, including ligand stimulated Hh pathway activity, was detected in hematopoietic malignancy cells, and determined to be associated with growth and proliferation of the malignancy cells. Accordingly, methods are provided for treating a hematopoietic cell malignancy associated with elevated Hh pathway activity by reducing or inhibiting the Hh pathway activity. Also provided are methods of determining the responsiveness of a hematopoietic cell malignancy to treatment with an Hh pathway antagonist.

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Dierks et al Nature Medicine vol. 13 p. 944 (Aug. 2007).
Mihich & Sellers, “Seventeenth Annual Pezcoller Symposium: Molecular Understanding of Solid Tumors”,Cancer Res., 65(24):11251-11254 (2005).

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