Compounds for eliciting or enhancing immune reactivity to...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Reexamination Certificate

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Reexamination Certificate

active

07601697

ABSTRACT:
Compounds and compositions for eliciting or enhancing immune reactivity to HER-2
eu protein are disclosed. The compounds include polypeptides and nucleic acid molecules encoding such peptides. The compounds may be used for the prevention or treatment of malignancies in which the HER-2
eu oncogene is associated.

REFERENCES:
patent: 3766162 (1973-10-01), Spector
patent: 3791932 (1974-02-01), Schuurs et al.
patent: 3817837 (1974-06-01), Rubenstein et al.
patent: 3850752 (1974-11-01), Schuurs et al.
patent: 3901654 (1975-08-01), Gross
patent: 3935074 (1976-01-01), Rubenstein et al.
patent: 3984533 (1976-10-01), Uzgiris
patent: 3996345 (1976-12-01), Ullman et al.
patent: 4034074 (1977-07-01), Miles
patent: 4098876 (1978-07-01), Piasio et al.
patent: 4233402 (1980-11-01), Maggio et al.
patent: 4452901 (1984-06-01), Gordon et al.
patent: 5320947 (1994-06-01), Cheever et al.
patent: 5401638 (1995-03-01), Carney et al.
patent: 5693522 (1997-12-01), Chada et al.
patent: 5958784 (1999-09-01), Benner
patent: 5985553 (1999-11-01), King et al.
patent: 6953573 (2005-10-01), Cheever et al.
patent: WO 90/14357 (1990-11-01), None
patent: WO 91/02062 (1991-02-01), None
Alper et al., “The Presence of c-erbB-2 Gene Product-related Protein in Culture Medium Conditioned by Breast Cancer Cell Line SK-BR-3,”Cell Growth&Differentiation 1:591-599, 1990.
Bargmann et al., “The neu oncogene encodes an epidermal growth factor receptor-related protein,”Nature 319:226-230, 1986.
Baselga et al., “Phase II Study of Weekly Intravenous Recombinant Humanized Anti-p185(^HER2) Monoclonal Antibody in Patients With HER2
eu-Overexpressing Metastatic Breast Cancer,”Journal of Clinical Oncology 14(3): 737-744, 1996.
Ben-Mahrez et al., “Circulating Antibodies Against C-myc Oncogene Product In Sera Of Colorectal Cancer Patients,”Int. J. Cancer 46: 35-38, 1990.
Ben-Mahrez et al., “Detectopm of circulating antibodies against c-myc protein in cancer patient sera,”British J. Cancer 57: 529-534, 1988.
Bishop and Orosz, “Limiting Dilution Analysis For Alloreactive, TCGF-Secretory T Cells. Two Related LDA Methods That Discriminate Between Unstimulated Precursor T Cells and In Vivo-Alloactivated T Cells,”Transplantation 47(4): 671-677, 1989.
Bodmer, W., “T-Cell Immune Responses to Cancer—A New Look,”Human Immunology 30:259-261, 1991.
Bowen-Pope et al., “Production of platelet-derived growth factor-like molecules and reduced expression of platelet-derived growth factor receptors accompany transformation by a wide spectrum of agents,”Proc. Natl. Acad. Sci. USA 81: 2396-2400, 1984.
Brooks et al., “Human lymphocyte markers defined by antibodies derived from somatic cell hybrids,”Clin. Exp. Immunol. 39: 477-485, 1980.
Brown et al., “Protein Antigens of Normal and Malignant Human Cells Identified by Immunoprecipitation with Monoclonal Antibodies,”Journal of Biological Chemistry 255(11): 4980-4983, 1980.
Burnette et al., “Western Blotting: Electropheretic Transfer of Proteins from Sodium Dodecyl Sulfate-Polyacrylamide Gels to Unmodified Nitrocellulose and Radiographic Detection with Antibody and Radioiodinated Protein A,”Analytical Biochemistry 112: 195-203, 1981.
Coussens et al., “Tyrosine Kinase Receptor with Extensive Homology to EGF Receptor Shares Chromosomal Location with neu Oncogene,”Science 230: 1132-1139, 1985.
Crystal, R.G., “In vivo and ex vivo gene therapy strategies to treat tumors using adenovirus gene transfer vectors,”Cancer Chemother. Pharmacol. 43(Suppl): S90-S99, 1999.
Davis, H.L. et al., “Direct Gene Transfer into Skeletal Muscle In Vivo: Factors Affecting Efficiency of Transfer and Stability of Expression,”Human Gene Therapy 4: 151-159, 1993.
Dhut et al, “BCR-ABL and BCR Proteins: Biochemical Characterization and Localization,”Leukemia 4(11): 745-750, 1990.
Disis et al., “Existent T-Cell and Antibody Immunity to HER-2
eu Protein in Patients With Breast Cancer,”Cancer Res. 54: 16-20, 1994.
Eck and Wilson, “Gene-based therapy,” inGoodman&Gilman 's The Pharmacological Basis of Therapeutics, 9thedition, McGraw-Hill, New York, 1996, pp. 77-101.
Falk et al., “Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules,”Nature 351: 290-296, 1991.
Feller and de la Cruz, “Identifying antigenic T-cell sites,”Nature 349: 720-721, 1991.
Fisk et al., “Oligopeptide Induction of a Cytotoxic T Lymphocyte Response to HER-2/Neu Proto-oncogene in Vitro,”Cellular Immunology 157:415-427, 1994.
Flanagan and Leder, “neu protooncogene fused to an immunoglobulin heavy chain gene requires immunoglobulin light chain for cell surface expression and oncogenic transformation,”Proc. Natl. Acad. Sci. USA 85: 8057-8061, 1998.
“Gene Therapy,” www.gateway.nlm.nih.gov. visted Jan. 23, 2004.
Igelhart et al., “Increased erbB-2 Gene Copies and Expression in Multiple Stages of Breast Cancer,”Cancer Research 50: 6701-6707, 1990.
Ioannides et al., “Antigens Recognized by T cells in Ovarian Cancer,” in Abstracts of the Fourth International Conference of Anticancer Research, Oct. 21-25, 1992, Rethymnon, Crete, Greece, p. 1870.
Ioannides et al., “CTL Clones Isolated from Ovarian Tumor Infiltrating Lymphocytes can Recognize Peptides with Sequences Corresponding to the HER2
eu Gene Product,”FASEB Journal 6: A1404, Abstract No. 2711, 1992.
Ioannides et al., “Cytotoxic T Cells Isolated From Ovarian Malignant Ascites Recognize a Peptide Derived From the HER-2
eu Proto-oncogene,”Cell. Immunol. 151: 225-234, 1993.
Ioannides et al., “Cytotoxic T-Cell Clones Isolated from Ovarian Tumour Infiltrating Lymphocytes Recognize Common Determinants on Non-Ovarian Tumour Clones,”Scand. J. Immunol. 37: 413-424, 1993.
Ioannides et al., “T-Cell Recognition of Oncogene Products: A New Strategy for Immunotherapy,”Molecular Carcinogenesis 6: 77-82, 1992.
Ioannides, “Antigens and vaccines of female genital cancers (Meeting abstract),” Cancerlit Database Abstract No. ICDB/93690682, 1992.
Ioannides, et al., “Cytotoxic T Cells Isolated From Ovarian Malignant Ascites Recognize a Peptide Derived From the HER-2
eu Proto-oncogene,”Cell. Immunol. 151:225-234, 1993.
Kallioniemi et al., “ERBB2 amplification in breast cancer analyzed by fluorescence in situ hybridization,”Proc. Natl. Acad. Sci. 89: 5321-5325, 1992.
Kerns et al., “c-erbB-2 Expression In Breast Cancer Detected by Immunoblotting and Immunohistochemistry,”Journal of Histochemistry and Cytochemistry 38(12): 1823-1830, 1990.
Laemmli, U., “Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4,”Nature 227: 680-685, 1970.
Leitzel et al., “Elevated Soluble c-erbB2 Antigen Levels in the Serum and Effusions of a Proportion of Breast Cancer Patients,”Journal of Clinical Oncology 10(9): 1436-1443, 1992.
Lichtenstein et al., “Effects of .beta.-2 Microglobulin Anti-sense oligonucleotides on Sensitivity of HER2
eu Oncogene-Expressing and Nonexpressing Target Cells to Lymphocyte-Mediated Lysis,”Cellular Immunology 141: 219-232, 1992.
Lippman, M., “Potential Contributions of Breast Cancer Biology to Management of Breast Cancer,”Advances in Oncology 8(3): 26-28, 1992.
Lippman, M., “Potential Contributions of Breast Cancer Biology to Management of Breast Cancer”,Advances in Oncology 8(3): 26-28, 1992.
Maguire and Greene, “The neu (c-erbB-2) Oncogene,”Seminars in Oncology 16(2): 148-155, 1989.
Margalit et al., “Prediction Of Immunodominant Helper T Cell Antigenic Sites From The Primary Sequence,”Journal of Immunology 138(7): 2213-2229, 1987.
McGlynn et al., “Large-scale purification and characterisation of a recombinant epid

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