Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Chemical modification or the reaction product thereof – e.g.,...
Reexamination Certificate
2007-06-12
2007-06-12
Le, Long V. (Department: 1641)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Chemical modification or the reaction product thereof, e.g.,...
C530S403000, C436S546000, C436S056000, C436S800000
Reexamination Certificate
active
10685172
ABSTRACT:
The invention discloses compounds and compositions for dual phototherapy and combined therapy and diagnosis of tumors and other lesions. The compounds have a Dye that, when photoactivated, operates via Type I and/or Type II mechanisms. Other Dye or azide components may operate by the same or different mechanisms. Selection of particular components in a compound, and formulation of the compound(s) in a composition permit different activation wavelengths to be used for different therapies. A targeting moiety may be added to the compound or composition so that the Dye locates at a particular site, such as a hormone-sensitive tumor, for diagnosis and/or treatment. The compounds and compositions may be incorporated within liposomes.
REFERENCES:
patent: 3887379 (1975-06-01), Clecak et al.
patent: 3996345 (1976-12-01), Ullman et al.
patent: 4818684 (1989-04-01), Edelman et al.
patent: 5395619 (1995-03-01), Zalipsky et al.
patent: 5518888 (1996-05-01), Waldman
patent: 5631018 (1997-05-01), Zalipsky et al.
patent: 5714342 (1998-02-01), Komoriya et al.
patent: 6004536 (1999-12-01), Leung et al.
patent: 6077584 (2000-06-01), Hurditch
patent: 6180085 (2001-01-01), Achilefu et al.
patent: 6217848 (2001-04-01), Achilefu et al.
patent: 6258378 (2001-07-01), Schneider et al.
patent: 6277403 (2001-08-01), Perez Mendez et al.
patent: 6406713 (2002-06-01), Janoff et al.
patent: 2004/0161430 (2004-08-01), Rajagopalan et al.
patent: 11174672 (1999-07-01), None
patent: WO02089858 (2002-11-01), None
patent: WO03003806 (2003-01-01), None
patent: WO03004091 (2003-01-01), None
patent: WO03004466 (2003-01-01), None
patent: WO03011106 (2003-02-01), None
patent: WO03065888 (2003-08-01), None
Byron Ballou et al.,Tumor labeling in vivo using cyanine-conjugated monoclonal antibodies, Cancer Immunology and Immunotherapy, vol. 41, 1995, 257-263.
Braun-Falco et al. (Eds.),Liposome Dermatics, Griesbach Conference, Springer-Verlag, Berlin 1992).
M.D. Daniel et al.,A History of Photodynamic Therapy, Aust. N.Z. J. Surg., vol. 61, 1991, 340-348.
T.J. Dougherty et al.,Photoradiation Therapy. II. Cure of Animal Tumors wiht Hematoporphyrin and Light, Journal of the National Cancer Institute, vol. 55, No. 1, 1975, 115-121.
G. Freiherr,The Light Stuff: Optical Imaging in Medical Diagnosis, Medical Device & Diagnostic Industry Magazine, 1998, 40-46.
M.R. Hamblin et al.,On the mechanism of the tumour-localising effect in photodynamic therapy, J. Photochem. Photobiol. B: Biol., vol. 23, 1994, 3-8.
Hamblin et al.,Targeted photodynamic therapy for infected wounds in mice, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XI (Proceedings of SPIE 2002) pp. 48-58.
J. C. Hebden et al.,Diagnostic Imaging with light, The British Journal of Radiology, vol. 70, 1997, S206-S214.
D.J. Hnatowich et al.,Radioactive Labeling of Antibody: A Simple and Efficient Method, Science, vol. 220, 1983, 613-615.
G. Jori,Far-red-absorbing photosensitizers: their use in the photodynamic therapy of tumours, J. Photochem. Photobiol. A: Chem., vol. 62, 1992, 371-378.
G. Jori et al.,Second Generation Photosensitizers for the Photodynamic Therapy of Tumours, Light in Biology and Medicine, vol. 2, R.H. Douglas et al. (Eds.), 1991, 253-266.
G. Jori,Tumour Photosensitizers: approaches to enhance the selectivity and efficiency of photodynamic therapy, Journal of Photochemistry and Photobiology B: Biology, vol. 36, 1996, 87-93.
G. Jori,Novel Therapeutic Modalities Based on Photosensitized Processes, Journal of Photochemistry and Photobiology B: Biology, No. 60, 1997, 12-18.
M. Korbelik,Photosensitizers in photodynamic therapy, Periodicum Biologorum, vol. 93, No. 4, 1991, 563-574.
Lasic & Martin, Eds.,Stealth Liposomes, 1995, CRC Press, London, pp.
K. Licha et al.,New contrast for optical imaging: acid-cleavable conjugates of cyanine dyes with biomedicals, In Biomedical Imaging: Reporters, Dyes, and Instrumentation, D.J. Bomhop, C. Contag, and E.M. Servick-Muraca (Eds.), Proceedings of SPIE, vol. 3600, 1999, 29-35.
R.L. Lipson, M.D. et al.,Hematoporphyrin Derivative for Detection and Management of Cancer, Cancer, vol. 20, No. 12, 1967, 2255-2257.
Y. Luo et al.,Rapid Initiation of Apoptosis by Photodynamic Therapy, Photochemistry and Photobiology, vol. 63, No. 4, 1996, 528-534.
K. Matsumura,1-Aminoacridine-4-carboxylic Acid, Journal of the American Chemical Society, vol. 60, (1938) 591-593.
G.G. Miller et al.,Preclinical assessment of hypocrellin B and hypocrellin B derivatives as sensitizers for photodynamic therapy of cancer: progress update, Photochemistry and Photobiology, vol. 65, No. 4, 1997, 714-722.
I. Ol'shevskaya,Cyanine dyes from azidobenzothiazole and benzimidazole, Chem. Ab. No. 1974:522571.
T. Parasassi et al.,Two-photon microscopy of aorta fibers shows proteolysis induced by LDL hydroperoxides, Free Radical in Biology and Medicine, vol. 28, No. 11, 2000, 1589-1597.
D.J. Pasto et al.,Demonstration of the Synthetic Utility of the Generation of Alkoxy Radicals by the Proto-Induced, Homolytic Dissociation of Alkyl 4-Nitrobenzenesulfenates, Tetrahedron Letters, vol. 35, No. 25, 1994, 4303-4306.
Patonay et al.,Near-Infrared Fluorogenic Labels: New Approach to and Old Problem, Anal. Chem., 63:6 (1991) pp. 321A-327A.
A. Pelegrin et al.,Photoimmunodiagnosis with antibody-fluorescein conjugates: in vitro and in vivo preclinical studies, J. Cell Pharmacol, vol. 3, 1992, 141-145.
V. Pochinok et al.,Photochemistry of azide group containing dyes in solution, Chem. Ab. No. 1984:439817.
Paras N. Prasad,Light-Activated Therapy: Photodynamic Therapy, Introduction to Biophotonics, 2003, J. Wiley & Sons, pp. 433-463.
W. G. Roberts et al.,Role of Neovasculature and Vascular Permeability on the Tumor Retention of Photodynamic Agents, Cancer Research, vol. 52, 1992, 924-930.
G.I. Stables et al.,Photodynamic therapy, Cancer Treatment Reviews, vol. 21, 1995, 311-323.
S. Sunthankar et al.,Reactive disperse dyes, 1, Reactivity involving nitrene intermediate from azido group, Indian Journal of Chemistry, 1974 11(5):503-504.
T. Takemura et al. ,Mechanism of Photodynamic Therapy: Exploration by Photophysiocochemical Study, Frontiers of Photobiology, 1993, 503-506.
K.B. Trauner et al.,Photodynamic Synovectomy Using Benzoporphyrin Derivative in an Antigen-Induced Arthritis Model for Rheumatoid Arthritis, Photochemistry and Photobiology, vol. 67, No. 1, 1998, 133-139.
P.J. van Geel et al.,Photosensitizing Efficacy of MTHPC-PDT Compared to Photofrin-PDT in the RIFI Mouse Tumour and Normal Skin, Int. J. Cancer, vol. 60, 1995, 388-394.
JE van Lier et al.,The chemistry, photophysics, and photosensitizing properties of phthalocyanines, Photosensitizing Compounds: Their Chemistry, Biology, and Clinical Use (Ciba Foundation Symposium 146), Bock and Hamett, Eds., J. Wiley & Sons, 1989, pp. 17-32.
EPO,Supplementary Partial European Search Report, EP02749597, 8 pg.
PCT,International Search Report, PCT/US2004/032859, International filing date Oct. 7, 1004, 5 pg.
Rajagopalan et al.,Targeted Type 1 phototherapeytic agents using azido-peptide bioconjugates, Proceedings of SPIE, 2001, vol. 4529: 129-132.
Achilefu Samuel I.
Bugaj Joseph E.
Dorshow Richard B.
Periasamy Muthunadar P.
Rajagopalan Raghavan
Mallinckrodt Inc.
Wood Herron & Evans LLP
LandOfFree
Compounds for dual photodiagnosis and therapy does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compounds for dual photodiagnosis and therapy, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compounds for dual photodiagnosis and therapy will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3853546