Compounds for diagnosis and/or therapy of tumours

Details Compounds for diagnosis and/or therapy of tumours Compounds for diagnosis and/or therapy of tumours

1995-06-07

2000-12-05

Feisee, Lila

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

53038822, 530412, 530413, 435326, C07K 100, C07K 1400, C12N 500

Patent

active

061568775

ABSTRACT:
Compounds are provided for use in the diagnosis and/or therapy of tumors and/or as immunosuppressive agent. The compounds are antibodies which bind to IL-4 receptors and IL-4 receptor-binding fragments thereof. A preferred compound is monoclonal antibody MR-6 produced by the hybridoma deposited at the European Collection of Animal Cell Cultures with the accession number 88033002. The invention also extends to the use of the compounds for in vitro removal of graft-versus-host reactive T-lymphocytes prior to bone marrow transplantation and to a novel protein of molecular weight 200,000 daltons functioning as a receptor for IL-4.

REFERENCES:
Jabaari et al "Elevated Expression of the interleukin 4 receptor in carcinoma: a target for immunotherapy?", Br. J. Cancer (1989) 59, 910-914.
Harris et al., FIBTECH 11:42-44, 1993.
Dillman, Annals of Internal Medicine, 111:592-603, 1989.
Hird et al., Genes and Cancer, John Wiley & Sonse, Ltd., 1990, 183-189.
Roitt et al, Immunology, 1993, Mosby, St Louis, p. 6.4-6.5.
Imani et al, Int. Immunol, 6:1575-1584, 1994.

Affiliated with

Also associated with

Rating

Compounds for diagnosis and/or therapy of tumours does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Compounds for diagnosis and/or therapy of tumours, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compounds for diagnosis and/or therapy of tumours will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-962744