Compounds exhibiting thrombopoietin-like activities

Details Compounds exhibiting thrombopoietin-like activities Compounds exhibiting thrombopoietin-like activities

2005-05-03

2005-05-03

Davis, Zinna Northington (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S415000, C514S616000, C546S255000, C548S454000, C564S155000

Reexamination Certificate

active

06887890

ABSTRACT:
The compounds of the invention are compounds represented by the following general formula (1):wherein E represents one selected from the group consisting of a methylidyne group and a nitrilo group, R1represents one selected from the group consisting of optionally substituted aryl groups and optionally substituted heteroaryl groups, R2represents one selected from the group consisting of a hydrogen atom and alkyl groups, W1represents an amino acid residue, A represents one selected from the group consisting of a carbonyl group and a sulfonyl group, X1represents one selected from the group consisting of optionally substituted alkylene groups and optionally substituted alkenylene groups, and p represents 0 or 1;and their pharmacologically acceptable salts, which exhibit thrombopoietin-like activity.

REFERENCES:
patent: 4695405 (1987-09-01), Harnisch et al.
patent: 01261650 (1989-10-01), None
patent: 10-212289 (1998-08-01), None
patent: 11-001477 (1999-01-01), None
patent: 11-152276 (1999-06-01), None
patent: WO 9640750 (1996-12-01), None
patent: WO 0028987 (2000-05-01), None
patent: WO 0035446 (2000-06-01), None
patent: WO 0066112 (2000-11-01), None
patent: WO 0107423 (2001-02-01), None
patent: WO 0117349 (2001-03-01), None
patent: WO 0121180 (2001-03-01), None
patent: WO 0134585 (2001-05-01), None
T.D. Bartley, et al.; “Identification and Cloning of a Megakaryocyte Growth and Development Factor That Is a Ligand for the Cytokine Receptor Mpl”; CELL; vol. 77; pp. 1117-1124; Jul. 1, 1994.
Frederic J. de Sauvage, et al.; “Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand”; NATURE; vol. 369; pp. 533-538; Jun. 16, 1994.
Steven E. Cwirla, et al.; “Peptide Agonist of the Thrombopoietin Receptor as Potent as the Natural Cytokine”; SCIENCE; vol. 276; pp. 1696-1699; Jun. 13, 1997.
Tatsuya Kimura, et al.; “A non-peptide compound which can mimic the effect of thrombopoietin via c-Mpl”; FEBS Letters 428; pp. 250-254; Apr. 21, 1998.
A. Kraft and F. Osterod, “Self-association of branched and dendritic aromatic amides”; J. Chem. Soc. Perkin Trans. 1; (1998); No. 6; pp. 1019-1025.

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