Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1987-09-29
1993-04-20
Dentz, Bernard
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514292, 514300, 514301, 514396, 514400, 544281, 546 84, 546121, 548154, 548335, 5483431, 5483435, 5483425, 5483461, 5483064, 5483107, 5483044, 5483301, 5483271, 5483411, A61K 31435, C07D47104
Patent
active
052043525
ABSTRACT:
Novel compounds are provided which exhibit high levels of anti-parasitic activity, specifically against parasites of the genus Trypanosoma. The compounds are comprised of aryl-substituted quaternary heteroaromatic salts which include a positively charged imidazolium or other heterocyclic ring, a linking group, a phenyl ring, and a polar functional group. The polar functional group is preferably a quanylhydrazone or a heterocyclic hydrazone. A method is also provided for treating the diseases associated with Trypanosoma parasites which comprises administering to infected animals or humans an effective amount of a compound of the present invention.
REFERENCES:
patent: 4044015 (1977-08-01), Kuhle
Winkelmann et al.-Forsch/Drug Research, 28(I) No. 5 (1978), pp. 739-749, rich et al., J. Med. Chem., 27, pp. 35-40 (1984).
Biswas Atanu
Dahlhausen Daniel J.
Manikumar Govindarajan
Mavunkel Babu J.
Musallam Hikmat A.
Bellamy Werten F. W.
Dentz Bernard
Moran John Francis
The United States of America as represented by the Secretary of
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