Compounds enhancing antitumor activity of other cytotoxic agents

Details Compounds enhancing antitumor activity of other cytotoxic agents Compounds enhancing antitumor activity of other cytotoxic agents

1995-09-20

2000-10-10

Bernhardt, Emily

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514252, 514318, 514211, 514321, 514326, 514367, 514278, 514290, 514319, 514320, 514322, 514323, 514324, 544364, 544366, 544368, 544370, 546194, 546198, 546209, 546 17, 546101, 546110, 546202, 548159, 548160, 548165, 540551, A61K 31495, C07D41712, C07D41714, C07D40312

Patent

active

061302171

ABSTRACT:
This invention relates to certain heterocyclic compounds and their pharmaceutically acceptable salts, which are useful for sensitizing multidrug-resistant tumor cells to anticancer agents and multidrug resistant forms of malaria, tuberculosis, leishmania and amoebic dysentery to chemotherapeutants. The compounds and their pharmaceutically acceptable salts are also inhibitors of the active drug transport capability of P-glycoprotein which is encoded by the human MDR1 gene, as well as of certain other related ATP-binding-cassette transporters from eukaryotic and prokaryotic organisms (e.g., pfmdr from Plasmodium falciprum, and murine mdr1 and mdr3 gene products).

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