Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-02-15
1996-09-03
Haley, Jacqueline
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
548507, A61K 3140, C07D20914
Patent
active
055524281
ABSTRACT:
The novel compounds of formula: ##STR1## in which R is isopropyl, cyclohexyl, phenyl, CH.sub.3, Br or I; or H R.sub.1 is CH.sub.3 or cyclopropyl and R.sub.2 is H or Br, and when R.sub.1 is cyclopropyl and R.sub.2 is H, R is other than H, and when R.sub.1 is CH.sub.3 and R.sub.2 is H, R is other than H, and when R.sub.1 is CH.sub.3 and R.sub.2 is H, R is other than I, and when R is CH.sub.3 and R.sub.2 is H, R.sub.1 is other than CH.sub.3, and when R is phenyl and R.sub.2 is H, R.sub.1 is other than CH.sub.3, exhibit superior activity in the treatment of pathologies which interfere with the circadian rhythm. A novel method of preparation is described according to which the pharmaceutical compositions containing the novel compounds, as well as compounds already known, are administered transdermally. The novel method of administration results in sustained peripheral blood level. Novel pharmaceutical compositions are described suitable for transdermal administration.
REFERENCES:
patent: 4087444 (1978-04-01), Flaugh et al.
patent: 5242941 (1993-09-01), Lewy et al.
patent: 5264219 (1993-11-01), Godbey et al.
patent: 5284660 (1994-02-01), Lee et al.
Borgonovo Margherita
Duranti, deceased Ermanno
Fraschini Franco
Introini Carlo
Laguzzi Aldo
Haley Jacqueline
Instituto Farmacologico Lombardo-IFLO, S.a.S.
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