Compounds effective in inducing cell differentiation and process

Details Compounds effective in inducing cell differentiation and process Compounds effective in inducing cell differentiation and process

1988-04-29

1990-05-22

Lipovsky, Joseph A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

9,10-seco- cyclopentanohydrophenanthrene ring system doai

552653, 552505, 552555, A61K 3159, C07J 900

Patent

active

049278150

ABSTRACT:
This invention provides novel side chain homologs of 1.alpha.,25-dihydroxyvitamin D.sub.3 which exhibit enhanced and highly selective activity in inducing differentiation of malignant cells. It also provides a general method of synthesis applicable to the preparation of a variety of vitamin D side chain analogs, and a method of treatment of neoplastic diseases which takes advantage of the selective differentiation activity of the new vitamin D homologs.

REFERENCES:
patent: 4717721 (1988-01-01), DeLuca et al.
patent: 4758382 (1988-07-01), Sterling et al.
patent: 4804502 (1989-02-01), Baggiolini et al.
Chemical Abstracts; vol. 109 (1988), #55060u; Kutner et al.
1,2,5-Dihydroxyvitamin D.sub.3 Analogs and Cell Differentiation; University of Wisconsin-Madison, Dept. of Biochemistry (1989); DeLuca et al.

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