Compounds derived from oxindoles and their therapeutic...

Details Compounds derived from oxindoles and their therapeutic... Compounds derived from oxindoles and their therapeutic...

2005-08-16

2005-08-16

McKane, Joseph K. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S418000, C548S468000, C548S486000

Reexamination Certificate

active

06930124

ABSTRACT:
The invention relates to compounds of formula (I)in which R5is chosen from the group consisting of:in which R2is a C1-C3alkyl groupin which X may be Cl, Br, or Fin which n is between 1 and 3, in the E or Z form, or a mixture of the two isomeric forms, possessing antimitotic, antiproliferative and antivascular properties through inhibition of the polymerization of tubulin into microtubules

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