Compounds containing a michael-acceptor, especially maleimide or

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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Details

514563, 548545, A61K 3140, C07D201448

Patent

active

058772049

ABSTRACT:
The present invention relates to compounds which are useful as sunscreens. The compounds persist on the skin for much longer than conventional sunscreens because they comprise a Michael acceptor linked directly or indirectly to a chromophore. The Michael acceptor is capable of undergoing a conjugate addition reaction with thiol groups present in cysteine residues of keratin and thus the compound is chemically bound to the skin and will not be removed by immersion in water.

REFERENCES:
patent: 3751449 (1973-08-01), Gobran et al.

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