Compounds containing a fused bicycle ring and processes therefor

Details Compounds containing a fused bicycle ring and processes therefor Compounds containing a fused bicycle ring and processes therefor

1994-05-05

1996-04-16

Grumbling, Matthew V.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

514211, 5142305, 5142285, 5142272, 540490, 544 48, 544 91, 544 92, 562556, 564502, 564503, 564504, 564505, A61K 31675, A61K 3155, C07D28102, C07D51302

Patent

active

055082726

ABSTRACT:
Compounds of the formula ##STR1## wherein X is O or S--(O).sub.t ; n is one or two; m is zero or one; Y is CH.sub.2, O, or S--(O).sub.t provided that Y is O or S--(O).sub.t only when m is one; and A is ##STR2## are dual inhibitors of NEP and ACE. Compounds wherein A is ##STR3## are selective ACE inhibitors. Also disclosed are methods of preparation and intermediates.

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