Compounds comprising gonadotropin releasing hormone (GnRH) and m

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514800, 530313, 930 20, 930 21, 930130, A61K 3809, C07K 723

Patent

active

056438770

ABSTRACT:
Novel peptide hormones which influence the release of gonadotropins by the pituitary gland in fish are disclosed. Methods in which such peptides may be administered to fish to control their reproduction are also described. Furthermore, novel isolated cDNA encoding the precursor of the novel gonadotropin-releasing hormone is disclosed. The use of such cDNA in controlling the gonadal development and spawning of fish is also described.

REFERENCES:
patent: 4410514 (1983-10-01), Vale, Jr. et al.
patent: 4443368 (1984-04-01), Sherwood et al.
patent: 4758552 (1988-07-01), Gulyas et al.
patent: 5076208 (1991-12-01), Zohar et al.
patent: 5093246 (1992-03-01), Cech et al.
patent: 5288705 (1994-02-01), Zohar
Adelman et al. "Isolation of the gene and hypothalamic cDNA for the common precursor of gonadotropin-releasing hormone and prolactin release-inhibiting factor in human and rat." Proc. Natl. Acad. Sci. USA 83: 179-183 (1986).
Alestrom et al. "Fish gonadotropin-releasing hormone gene and molecular approaches for control of sexual maturation: Development of a transgenic fish model." Mol. Marine Biol. and Biotech. 1(4/5): 376-379 (1992).
Amoss et al. "Purification, amino acid composition and N-terminus of the hypothalamic luteinizing hormone releasing factor (LFR) of ovine origin". Biochem. Biophys. Res. Commun. 44: 205-210 (1971).
Ashihara et al. Sequence listing copied from a poster which appeared at the IUBS Symposium on "Advances in the Molecular Endocrinology of Fish," May 23-25, 1993, Toronto, Canada. Copy of poster is unavailable; Abstract P4, (1994).
Ausubel et al. (Eds.) Current Protocols in Molecular Biology, vols. I & II, Green Publishing Associates, Inc. and John Wiley & Sons, Inc., New York, 1989.
Okuzawa et al. Gen. Compar. Endocrinol. 96(2):234-42, 1994.
Bogerd et al. "Isolation, characterization and epxression of cDNAs encoding the catfish-type and chicken-II-type gonadotropin-releasing-hormone precursors in the African catfish." Eur. J. Biochem. 222(2): 541-549 (1994).
Bond et al. "Characterization of complementary DNA encoding the precursor for gonadotropin-releasing hormone and its associated peptide from a teleost fish". Mol. Endocrinol. 5: 931-937 (1991).
Chen et al. "Transgenic fish". Tibtech 8: 209-215 (1990).
Conlon et al. "Two molecular forms of gonadotropin-releasing hormone from the brain of the frog, Rana ridibunda: Purification, characterization, and distribution". Endocrinol. 132: 2117-2123 (1993).
Copeland et al. "Luteinizing hormone-releasing hormone: Sequential versus conformational specificity of antiluteinizing hormone-releasing hormone sera". Endocrinology 104: 1504-1512 (1979).
Dunn et al. "Characterization of the chicken preprogonadotrophin-releasing hormone-I gene". J. Mol. Endocrinol. 11: 19-29 (1983).
Hayes et al. "The frog gonadotropin-releasing hormone-I (GnRH-I) gene has a mammalian-like expression pattern and conserved domains in GnRH-associated peptide, but brain onset is delayed until metamorphosis". Endocrinol. 134(4): 1835-1845 (1984).
Kelsall et al. "Phylogeny and ontogeny of gonadotropin-releasing hormone: Comparison of guinea pig, rat, and a protochordate". Gen. Comp. Endocrinol. 78:479-494 (1990).
King et al. "Structure of chicken hypothalamic luteinizing hormone releasing hormone". J. Biol. Chem. 257: 10729-10732 (1982).
King et al. "Chromatographic and immunological evidence for mammalian GnRH and chicken GnRH II in eel (Anguilla anguilla) brain and pituitary". Peptides 11: 507-514 (1990).
Klungland et al. "The Atlantic salmon prepro-gonadotropin releasing hormone gene and mRNA". Mol. and Cell. Endocrinol. 84: 167-174 (1992).
Kozak. "Possible role of flanking nucleotides in recognition of the AUG initiator codon by eukaryotic ribosomes". Nucl. Acids Res. 9: 5233-5252 (1981).
Lin et al. "Effects of [D-Ala.sup.6, Pro.sup.9 -NEt]-LHRH and catecholaminergic drugs on gonadotropin secretion and ovulation in the Chinese Loach (Paramisgurnus dabryanus)." Gen. Comp. Endocrinol. 64: 389-395 (1986).
Lovejoy et al. "Distinct sequence of gonadotropin-releasing hormone (GnRH) in dogfish brain provides insight into GnRH evolution". Proc. Natl. Acad. Sci. USA 89: 6373-6377 (1992).
Mason et al. "The hypogonadal mouse: Reproductive functions restored by gene therapy". Science 234: 1372-1378 (1986).
Matsuo et al. "Structure of the porcine LH- and FSH-releasing hormone. I. The proposed amino acid sequence". Biochem. Biophys. Res. Commun. 43: 1334-1339 (1971).
Miyamoto et al. "Identification of the second gonadotropin-releasing hormone in chicken hypothalamus: Evidence that gonadotropin secretion is probably controlled by two distinct gonadotropin-releasing hormones in avian species". Proc. Natl. Acad. Sci. USA 81: 3875-3878 (1984).
Ngamvongchon et al. "Primary structures of two forms of gonadotropin-releasing hormone, one distinct and one conserved, from catfish brain." Mol. Cell. Neurosci. 3: 17-22 (1992).
Peter et al. "Gonadotropin release from the pars distalis of goldfish, Carassius auratus, transplanted beside the brain or into the brain ventricles: Additional evidence for gonadotropin-release-inhibitory factor". Gen. Comp. Endocrinol. 55: 337-346 (1984).
Peter et al. "Induced ovulation and spawning of cultured freshwater fish in China: Advances in application of GnRH analogues and dopamine antagonists". Aquaculture 74: 1-10 (1988).
Rivier et al. "Reversed-phase high-performance liquid chromatography: Preparative purification of synthetic peptides". J. Chromatog. 288: 303-328 (1984).
Rivier et al. "Gonadotropin-releasing hormone antagonists with N.sup..omega. -Triazolylornithine, -lysine, or -p-aminophenylalanine residues at positions 5 and 6". J. Med. Chem. 35: 4270-4278 (1992).
Sambrook et al. Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratories Press, Cold Spring Harbor, NY, 1989; (cover pages provided).
Schally et al. "Isolation and properties of the fish and LH-releasing hormone". Biochem. Biophys. Res. Commun. 43: 393-399 (1971).
Seeburg & Adelman. "Characterization of cDNA for precursor of human luteinizing hormone releasing hormone". Nature 311: 666-668 (1984).
Sherwood et al. "Characterization of a teleost gonadotropin-releasing hormone". Proc. Natl. Acad. Sci. USA 80: 2794-2798 (1983).
Sherwood et al. "Primary structure of a gonadotropin-releasing hormone from Lamprey brain". J. Biol. Chem. 261: 4812-4819 (1986).
Sherwood et al. "Gonadotropin-releasing hormone (GnRH) in bony fish that are phylogenetically ancient: Reedfish (Calamoichthys calabaricus), sturgeon (Acipenser transmontanus), and alligator gar (Lepisosteus spatula)." Gen. Comp. Endocrinol. 84: 44-57 (1991).
Sherwood et al. "Gonadotropin-releasing hormones, including a novel form, in snook Centropomus undecimalis, in comparison with forms in black sea bass Centropristis striata". Regul. Pept. 46: 523-534 (1993).
Sower et al. "Primary structure and biological activity of a third gonadotropin-releasing hormone from Lamprey brain". Endocrinol. 132: 1125-1131 (1993).
Stacey et al. "Ovulatory surge of gonadotropin in the goldfish, Carassius auratus". Gen. Comp. Endocrinol. 37: 246-249 (1979).
Suzuki et al. "Characterization and localization of mRNA encoding the salmon-type gonadotrophin-releasing hormone precursor of the masu salmon". J. Mol. Endocrin. 9: 73-82 (1992).
Wetsel et al. "Metabolism of pro-luteinizing hormone-releasing hormone in immortalized hypothalamic neurons". Endocrinology 129: 1584-1595 (1991).
White et al. "A second gene for gonadotropin-releasing hormone: cDNA and expression pattern in the brain". Proc. Natl. Acad. Sci. USA 91: 1423-1427 (1994).
Zohar et al. "Spawning kinetics in the gilthead sea-bream, Sparus aurata L. after low doses of human chronic gonadotropin". J. Fish Biol. 15: 665-670 (1979).
Zohar et al. "Short-term profiles of plasma gonadotropin and 17.alpha.-hydroxy, 20+62 -dihydroprogesterone levels in the female rainbow trout at the periovulatory period". Gen. Comp. Endocrinol. 64: 189-198 (1986).
Zohar et al. "Gonadotropin Biodynamics Following GnRH administration oin the gilthead seabream, Sparus aurata: a combined radioimminoa

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Compounds comprising gonadotropin releasing hormone (GnRH) and m does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Compounds comprising gonadotropin releasing hormone (GnRH) and m, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compounds comprising gonadotropin releasing hormone (GnRH) and m will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-597117

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.