Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai
Reexamination Certificate
2005-11-15
2005-11-15
Jones, Dwayne (Department: 1614)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ester doai
C514S532000, C514S534000
Reexamination Certificate
active
06964982
ABSTRACT:
The present invention provides compositions and methods for prevention and prophylaxis of neurological diseases accompanied by neuronal death. The invention includes synthesis of 5-benzylamino salicylic acid (BAS) and its derivatives. BAS and its derivatives protect cortical neurons from toxic insults by N-methyl-D-aspartate, Zn2+, and reactive oxygen species. Thus, the present invention provides compositions and methods for treating stroke, traumatic brain and spinal cord injury, epilepsy, and neurodegenerative diseases that are accompanied by severe neuronal loss via excitotoxicity, Zn2+neurotoxicity, and free radical neurotoxicity.
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Gwag Byoung Joo
Lee Young Ae
Moon Ho Sang
Ryu Bo Rum
Yoon Sung Hwa
Jones Dwayne
Neurotech Co., Ltd.
Reed Smith LLP
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