Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-03-01
2005-03-01
Reamer, James H (Department: 1614)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S403000, C514S359000, C514S260100, C514S293000, C514S374000, C514S256000, C514S264110, C514S267000, C514S383000, C514S367000
Reexamination Certificate
active
06861431
ABSTRACT:
Methods of modulating the activity of multidrug transporters are disclosed. The methods of modulating the activity of multidrug transporters use compounds that selectively increase or decrease the efflux capabilities of the multidrug transporter. The methods can be used therapeutically to enhance performance of therapeutic drugs, like chemotherapeutic drugs and antibiotics; to promote detoxification of cells and tissues; and to increase or decrease the efficacy of the blood-brain barrier or placental barrier.
REFERENCES:
patent: 5403574 (1995-04-01), Piwnica-Worms
patent: 6025473 (2000-02-01), Deeley et al.
patent: 20020037843 (2002-03-01), Reiner et al.
patent: 20020128264 (2002-09-01), Taylor
patent: WO 9939731 (1999-08-01), None
patent: WO 0044364 (2000-08-01), None
patent: WO 0046347 (2000-08-01), None
patent: WO 0180896 (2001-11-01), None
patent: WO 0214321 (2002-02-01), None
M.M. Gottesman et al.,Annu. Rev. Biochem., 62, pp. 385-427 (1993).
B. Tan et al.,Curr. Opin. Oncol., 125, pp.50-58 (2000).
A.H. Schinkel et al.,Cell, 77, pp. 491-502 (1994).
A. Lorico et al.,Cancer Res., 57, pp. 5238-5242 (1997).
J.J. Smit et al.,Cell, 75, pp. 451-462 (1993).
K.H. Choi et al.,Cell, 53, pp. 519-529 (1988).
S. Kajiji et al.,Biochemistry, 32, pp. 4185-4194 (1993).
C.A. Hrycyna et al.,Methods Enzymol., 292, pp. 456-473 (1998).
R.S. Gupta,Biochem. Biophys. Res. Commun., 153, pp.598-605 (1988).
S. Akiyama et al.,Somat. Cell. Mol. Genet., 11, pp. 117-126 (1985).
J.M. Phang et al.,Cancer Res., 53, pp. 5977-5981 (1993).
J.M. Critchfield et al.,Biochem. Pharmacol., 48, pp. 1437-1445 (1994).
G. Scambia et al.,Cancer Chemother. Pharmacol., 34, pp. 459-464 (1994).
J. Ferte et al.,J. Med. Chem., 42, pp. 478-489 (1999).
D.F. Robbiani et al.,Cell, 103, pp. 757-768 (2000).
P.G. Komarov et al.,Science, 285, pp. 1733-1737 (1999).
P. Borst,Seminars in Cancer Biology, 8, pp. 131-134 (1997).
J. Konig et al.,BBA, 1461, pp. 377-394 (1999).
B. Sarkadi et al.,Seminars in Cancer Biology, 8, pp. 171-182 (1997).
A. Schinkel,Seminars in Cancer Biology, 8, pp. 161-170 (1997).
A.H. Schinkel et al.,Proc. Natl. Acad. Sci. USA, 94, pp. 4028-4033 (1997).
P. Gros et al.,Proc. Natl. Acad. Sci. USA, 88, pp. 7289-7293 (1991).
A.R. Safa et al.,Proc. Natl. Acad. Sci. USA, 87, pp. 7225-7229 (1990).
E.B. Mechetner et al.,Proc. Natl. Acad. Sci. USA, 94, pp. 12908-12913 (1997).
A.B. Shapiro et al.,Eur. J. Biochem., 259, pp. 841-850 (1999).
S.L. Bogza et al.,J. Heterocyclic Chem., 38, 523 (2001).
A. Singh et al.,Indian J. Chem., vol. 14B, No. 12, 997-998 (1976).
M.N. Balse et al.,Indian Journal of Chemistry, vol. 19B, 263-265 (1980).
U. Heinz et al.,Zeitschrift Fuer Kristallographie, vol. 216, No. 1, 113-114 (2001).
R.V. Kondratov et al., Proceedings of the National Academy of Sciences of the United States of America, vol. 98, No. 24, 14078-14083 (2001).
Gudkov Andrei
Kondratov Roman
Marshall & Gerstein & Borun LLP
Reamer James H
The Board of Trustees of the University of Illinois
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