Compounds capable of modulating the activity and stimulating...

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 4 to 5 amino acid residues in defined sequence

Reexamination Certificate

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Reexamination Certificate

active

07109291

ABSTRACT:
The invention concerns novel compounds capable of modulating the activity and stimulating the production of catalytic antibodies. More particularly, the invention concerns a compound capable of increasing the activity of an antibody having specific affinity for the catalytic site of the antibody, and it is not immunogenic. Such compounds are useful in particular for therapeutic treatment or prevention of a pathology related to an enzymatic deficiency, to stimulate in vivo hydrolysis of xenobiotics, drugs, medicines or any other molecule potentially toxic for the organism or for preventing or inhibiting allergic reactions.

REFERENCES:
patent: 5948658 (1999-09-01), Landry
patent: 6048717 (2000-04-01), Paul
patent: 6235714 (2001-05-01), Paul
patent: 3841767 (1988-12-01), None
patent: WO 90/06939 (1990-06-01), None
patent: WO 96/34887 (1996-11-01), None
patent: WO 99/48925 (1999-09-01), None
Biotechterms.org, analogue, 2001, http://biotechterms.org/sourcebook/saveidretrieve.php3?id=99, printed Sep. 20, 2004, p. 1.
Lefevre et al., “A suicide-substrate mechanism for hydrolysis of beta-lactams by an anti-idiotypic catalytic antibody.” FEBS Lett. 489(1):25-8 (2001).
Du et al., “A New Monoclonal Anti-idiotypic Catalytic Antibody with a CPA-like Activity.” Bioorg. & Med. Chem. Lett. 9:1487-1492 (1999).

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