Compounds as anti-inflammatory, immunomodulatory and...

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof

Reexamination Certificate

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C562S622000, C514S563000

Reexamination Certificate

active

07071355

ABSTRACT:
The present invention relates to compounds of the general formula (I) and salt and physiologically functional derivatives thereof,whereinA is a non-aromatic ring system containing 4 to 8 carbon atoms, wherein the ring system comprises at least one double bond and wherein one or more of the carbon atoms in the ring can be replaced by a group X, wherein X is selected from the group consisting of S, O, N, NR4, SO, CO or SO2;D is O, S, SO2, NR4or CH2;Z1and Z2are independent from each other O, S, or NR5;R2is H, OR6, or NHR7;E is an alkyl or cycloalkyl group or a monocyclic or polycyclic substituted or unsubstituted ring system which may contain one or more groups X and which contains at least one aromatic ring;Y is hydrogen, halogen, haloalkyl, haloalkyloxy, alkyl, cycloalkyl, a monocyclic or polycyclic substituted or unsubstituted ring systemfor the use as a medicament.

REFERENCES:
patent: 3465001 (1969-09-01), Bolhofer et al.
patent: 4661630 (1987-04-01), Harigaya et al.
patent: 5262537 (1993-11-01), Huang et al.
patent: 5886033 (1999-03-01), Schwab et al.
patent: 28 51 379 (1979-05-01), None
patent: 29 21 002 (1979-11-01), None
patent: 33 46 814 (1984-06-01), None
patent: 35 21 303 (1985-10-01), None
patent: 39 33 573 (1991-04-01), None
patent: 195 39 638 (1997-04-01), None
patent: 0 097 056 (1983-12-01), None
patent: 0 337 263 (1989-10-01), None
patent: 0 418 667 (1991-03-01), None
patent: 0 419 944 (1991-04-01), None
patent: 0 440 503 (1991-08-01), None
patent: 0 463 444 (1992-01-01), None
patent: 0 503 410 (1992-09-01), None
patent: 0 573 318 (1993-12-01), None
patent: 2 158 440 (1985-11-01), None
patent: 2-22650 (1990-01-01), None
patent: WO 98/57937 (1998-12-01), None
patent: WO 99/65867 (1999-12-01), None
patent: WO 01/21160 (2001-03-01), None
patent: WO 01/24785 (2001-04-01), None
patent: WO 02/38153 (2002-05-01), None
patent: WO 02/100851 (2002-12-01), None
patent: WO 03/006424 (2003-01-01), None
patent: WO 03/006425 (2003-01-01), None
patent: WO 03/006443 (2003-01-01), None
Maruyama et al, J. Org. Chem, 1985, 50, 4742-4749.
E. Kita, et al. Polish Journal of Chemistry, vol. 53, No. 6, pp. 1211-1219, “Protolytic Equilibriums of 4-Pyridoxyl-4, 5, 6, 7-Tetrahydropyrido-[3,4-C] Imidazole and its Derivatives”, 1979 (submitting Chemical Abstracts only, An 1979; 592609).
F. Thorstensson, et al., Journal of Medicinal Chemistry, vol. 46, No. 7, XP-002274167, pp. 1165-1179, “Synthesis of Novel Thrombin Inhibitors. Use of Ring-Closing Metathesis Reactions for Synthesis of P2 Cyclopentene- and Cyclohexenedicarboxylic Acid Derivatives”, 2003.
S.-F. Chen, et al., Biochemical Pharmacology, vol. 40, No. 4, XP-000900094, pp. 709-714, “Structure-Activity Relationship of Quinoline Carboxylic Acids. A New Class of Inhibitors of Dihydroorotate Dehydrogenase”, 1990.
J. V. De Julian-Ortiz, et al., Journal of Medicinal Chemistry, vol. 42, XP-002199074, pp. 3308-3314, “Virtual Combinatorial Syntheses and Computational Screening of New Potential Anti-Herpes Compounds”, 1999.
Takeda Chemical Industries, et al., Chemical Abstracts+ Indexes, vol. 94, No. 25, XP-002199076, 1 page, “Tetrahydrophthalamide Derivatives”, Jun. 22, 1981.
Matsui, et al., Chemical Abstracts+Indexes, vol. 84, No. 5, XP-002199075, 1 page, “N-Substituted-Δ'-Cyclopentene-1, 2-Dicarboxylic Acid Monoamides as Herbicides”, Feb. 2, 1976.
E. Campaigne, et al., J. Med. Chem., vol. 12, No. 2, XP-002278920, pp. 339-342, “Synthesis of Some Ureidodihydrofurans and Related Pyrimidones as Potential Antimalarials”, 1969.
T. Trnovec, et al., Die Pharmazie, vol. 40, No. 6, XP-002275746, pp. 410-411, “Pharmacokinetics of Ethimizol in Man”, Jun. 1985.
W. Küster, et al., Berichte Der Deutschen Chemischen Gesellschaft, vol. 57, No. 3, XP-002275747, pp. 409-413, “Über die Bildung von Pyrrol-Derivaten aus Amined von Beta-Diketonsäure-Estern.”, Mar. 12, 1924.
N. Yasuda, Journal of Heterocyclic Chemistry, vol. 22, XP-002275748, pp. 413-416, “Synthesis of Novel Imidazole-4, 5-Dicarboxylic Acid Derivatives”, 1985.
A. J. Carpenter, et al., Journal of Organic Chenistry, vol. 50, No. 22, XP-002275749, pp. 4362-4368, “The Scope and Limitations of Carboxamide-Induced β-Directed Metalation of 2-Substituted Furan, Thiophene, and 1-Methylpyrrole Derivatives. Application of the Method to Syntheses of 2, 3-Disubstituted Thiophenes and Furans”, Nov. 1, 1985.
U.S. Appl. No. 10/736,711, filed Dec. 17, 2003, Leban et al.
U.S. Appl. No. 10/736,742, filed Dec. 17, 2003, Leban et al.
U.S. Appl. No. 10/736,739, filed Dec. 17, 2003, Leban et al.

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