Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2004-06-07
2008-12-16
Wilson, James O (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C544S250000
Reexamination Certificate
active
07465739
ABSTRACT:
Thiophenepyrimidinone compounds and their use in therapy, especially for use in the treatment and/or prevention of a steroid hormone dependent diseases or disorders, such as steroid hormone dependent diseases or disorders requiring inhibition of 17β-hydroxysteroid dehydrogenase enzymes.
REFERENCES:
patent: 5597823 (1997-01-01), Meyer et al.
patent: 6541463 (2003-04-01), Labrie et al.
patent: 2003/0170292 (2003-09-01), Yong et al.
patent: 0 364 598 (1990-04-01), None
patent: 48042271 (1973-06-01), None
patent: 62132884 (1987-06-01), None
patent: WO 98/30556 (1998-07-01), None
patent: WO 98/32724 (1998-07-01), None
patent: WO 99/12540 (1999-03-01), None
patent: WO 00/07996 (2000-02-01), None
patent: WO 01/42181 (2001-06-01), None
patent: WO 02/26706 (2002-04-01), None
patent: WO 03/017973 (2003-03-01), None
patent: WO 03/022835 (2003-03-01), None
Manhas, et al., Heterocyclic Compounds. 4. Synthesis and Antiinflammatory Activity of Some Substituted Thienopyrimidones, Journal of Medicinal Chemistry, pp. 106-107, vol. 15, No. 1 (1971).
Manhas, et al., Heterocyclic Compounds. VI. Synthesis of Polynuclear Thienopyrimidine Derivatives (1), J. Heterocyclic Chemistry, 13, 903-906(1976).
Shishoo, C.J., et al., Studies on the Synthesis of 2-(2-Arylvinyl)thieno[2,3-d]pyrimidines and 5-(2-Arylvinyl)triazolothieno[3,2-e]pyrimidines, J. Heterocyclic Chem., 22 825-830 (1985).
Smith et al., Inhibitors of Steroidogenesis as Agents for the Treatment of Hormone-dependent Cancers, Expert Opinion on Therapeutic Patents, vol. 11(5), pp. 789-824 (2001).
Nakanishi, Michio et al., “Benzothienopyrimidine Derivatives”, Yoshitomi Pharmaceuticals Industries, Ltd., May 12, 1984, pp. 3, XP002329947.
El-Telbany, Farag A., “Synthesis of Some Substituted Thienopyrimidiones1” Pharmazie, 1980, pp. 326 & 327, XP008047716.
Shishoo, CJ, “Reaction of Nitriles Under Acidic Conditions: Part IV-Synthesis of Some 2-Substituted Quinazolin-4Ones and Thienopyrimidin-4-Ones of Biological Interest and Isolation of O-Functionalized Amidine Intermediates”, Indian J. Chemistry, Dec. 1989, pp. 1039-1047, vol. 28B, XP-000983872.
El-Zanfally, S. H., et al., “Synthesis and Biological Activity of Certain Substituted Thienopyrimidiones”, Orient. Journal of Chemistry, 1989, pp. 242-246, vol. 5, No. 3, XP008047626.
Kulshreshtha, M. J. (MRS.), et al., “Synthesis of 2-Methyl, 3-Aryl or Arylalkyl 5, 6-Dimethyl or Polymethylene Thieno [2,3-d]-Pyrimidine-4-Ones”, J. Indian Chem. Soc., Oct. 1981, pp. 982-984, vol. LVIII, XP008047632.
Stefan Andersson, “Molecular Genetics of Androgenic 17β-Hydroxysteroid Dehydrogenases”, J. Steroid Biochem. Molec. Biol., 1995, pp. 533-534, vol. 55, No. 5/6, Elsevier Science Ltd., Great Britain.
Fernand Labrie et al., “The Key Role of 17 β-Hydroxysteroid Dehydrogenases in Sex Steroid Biology”, Steroids, Jan. 1997, pp. 148-158, vol. 62, Elsevier Science Ltd., New York, New York, USA.
Donald Poirier, “Inhibitors of 17 β-Hydroxysteroid Dehydrogenases”, Current Medicinal Chemistry, 2003, pp. 453-477, vol. 10, No. 6, 2003 Bentham Science Publishers Ltd.
T. Tamaya et al., “Comparison of Cellular Levels of Steroid Receptors in Uterine Leiomyoma and Myometrium”, Acta Obstet Gynecol Scand, 1985, pp. 307-309, 64.
Yu Dong et al., “17 β-Hydroxysteroid Dehydrogenases in Human Bone Cells”, Journal of Bone and Mineral Research, 1998, pp. 1539-1546, vol. 13, No. 10, American Society for Bone and Mineral Research.
Fernand Labrie et al., “Role of 17 β-Hydroxysteroid Dehydrogenases in Sex Steroid Formation in Peripheral Intracrine Tissues”, TEM, 2000, pp. 421-427, vol. 11, No. 10, Elsevier Science Ltd.
M.S. Manhas et al., “Heterocyclic Compounds 4. Synthesis and Antiinflammatory Activity of Some Substituted Thienopyrimidones”, Journal of Medicinal Chemistry, pp. 106-107, vol. 15, No. 1.
Michael G. Oefelein et al., “Failure to Achieve Castrate Levels of Testosterone During Luteinizing Hormone Releasing Hormone Agonist Therapy: The Case for Monitoring Serum Testosterone and a Treatment Decision Algorithm”, The Journal of Urology, Sep. 2000, pp. 726-729, vol. 164, American Urological Association, Inc., USA.
B. Koffman et al. “Evidence for Involvement of Tyrosine in Estradiol Binding by Rat Uterus Estrogen Receptor”, J. Steroid Biochem. Molec. Biol., 1991, pp. 135-139, vol. 38, No. 2, Pergamon Press plc., Great Britain.
Wayne M. Geissler et al., “Male Pseudohermaphroditism Caused by Mutations of Testicular 17 β-Hydroxysteroid Dehydrogenase 3”, Nature Genetics, May 1994, pp. 34-39, vol. 7.
M.V. Kapustina et al., “Synthesis and Antiviral Activity of 7-OXO- and 7-Hydroxy-4,5,6,7-Tetrahydrobenzo [b] Thiophene Derivatives”, 1991, pp. 269-271, Plenum Publishing Corporation; Translated from Khimiko-Farmatsevticheskii Zhurnal, vol. 24, No. 4, pp. 39-34, Apr. 1990, All-Union Scientific Research Institute of Pharmaceutical Chemistry.
Andanappa K. Gadad et al., “Synthesis and Antihyperlipaemic Activity of Some 2-Aminomethyl-3-aryl-5,6,7,8-tetrahydrobenzo(b)/5,6-dimethylthieno(2,3-d)-pyrimidin-4-ones”, Arzneim.-Forsch./Drug Research, 1996, pp. 981-985, 46, No. 10.
Michael Gütschow et al., “2-(Diethylamino)thieno[1,3]oxazin-4-ones as Stable Inhibitors of Human Leukocyte Elastase”, J. Med. Chem., 1999, pp. 5437-5447, vol. 42, No. 26, American Chemical Society.
M.V. Kapustina et al., “Synthesis of 6-Phenylthiobenzo[b]Thiophenes”, 1991, pp. 425-427, 1991 Plenum Publishing Corporation, Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 534-536, All-Union Scientific Research Institute, Moscow.
M.V. Kapustina et al., “Synthesis 6-Formylbenzo (b) Thiophene Derivatives and Their Antiviral Activity”, 1992, pp. 789-794, 1992 Plenum Publishing Corporation, Translated from Khimiko-Farmatsevticheskii Zhurnal, 25(11), 30-3; All-Union Scientific Research Institute, Moscow.
S. Koeller et al., “Preparation of Formate Esters from O-TBDMS/O-TES Protected Alcohols. A One-Step Conversion Using the Vilsmeir-Haack Complex POCI3/DMF”, Tetrahedron Letters, 1999, pp. 7043-7046, 40, Elsevier Science Ltd.
Pelle Lidström et al., “Microwave Assisted Organic Synthesis-a Review”, Tetrahedron, 2001, pp. 9225-9283, 57, report No. 589, Elsevier Science Ltd.
Bruce H. Lipshutz et al., “Conjugate Addition Reactions of α,β-Unsaturated Ketones with Higher Order, Mixed Organocuprate Reagents, R2Cu(CN)Li2”, J. Org. Chem., 1984, pp. 3938-3942, vol. 49, No. 21, American Chemical Society.
I. A. Kharizomenova et al., “Synthesis and Structure of Derivatives of 7-OXO-4,5,6,7-Tetrahydrobenzo [b]- Thiophene and 7-Hydroxybenzo [b] Thiophene”, 1984, 1339-1342, Plenum Publishing Corporation, Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 12, pp. 1626-1629, S. Ordzhonikidze All-Union Pharmaceutical Chemistry Research Institute, Moscow.
Kadthala Shekar Manjunath et al., “Synthesis and Evaluation of 2-Chloromethyl-3-N-substituted Arylthieno (2,3-d)pyrimidin-4-ones and Derivatives for Central Nervous System Depressant Activity”, Arzneim-Forsch/ Drug Res., 1997, pp. 1005-1008, 47, No. 9.
R.B. Mitra et al., “A Novel Synthesis of Ketroprofen, Important Non-Steroidal Antiinflammatory Agent”, Synthetic Communications, 1988, pp. 2259-2265, 18 (18), Marcel Dekker, Inc.
Monique Perrissin et al., “Tétrahydro-4,5,6,7 benzo (b) et tétrahydro-5,6,7,8 4Hcyclohepta (b) thiophéne”, Eur. J. Med. Chem., Sep.-Oct. 1980, pp. 413-418, 15, No. 5.
Subhendu Sekhar Samanta et al., Studies in Sulfur Heterocycles. Part 12.1Use of 5,6-dihydrobenzo[b]-thiophen-7(4H)-one in the synthesis of condensed sulfur heterocycles, J. Chem. Soc., Perkin Trans. 1, 1997, pp. 3673-3677.
Masanobu Tani et al., New Strategy for Indole Synthesis from Ethyl Pyrrole
Hirvelae Leena
Johansson Nina
Johnson Mark
Koskimies Pasi
Lehtovuori Pekka
Crowell & Moring LLP
Leeser Erich A
Solvay Pharmaceuticals B.V.
Wilson James O
LandOfFree
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