Compounds and their combinations for the treatment of influenza

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514 18, A61K 3805

Patent

active

060136324

ABSTRACT:
Administration of one or more of glutathione, its disulfide dimer, ascorbate-2-phosphate, or N-acetyl-L-cysteine, with or without antioxidants, is suitable for the treatment of influenza virus infection, as well as prophylactic prevention of influenza virus infection.

REFERENCES:
patent: 3184505 (1965-05-01), Martin et al.
patent: 3439089 (1969-04-01), Cherkas
patent: 4046879 (1977-09-01), Swetly
patent: 4689347 (1987-08-01), Dinu et al.
patent: 4867973 (1989-09-01), Rodwell et al.
patent: 4965066 (1990-10-01), Hussain
patent: 5011678 (1991-04-01), Wang et al.
patent: 5091171 (1992-02-01), Yu et al.
patent: 5135730 (1992-08-01), Suzuki et al.
patent: 5164398 (1992-11-01), Sims et al.
patent: 5208249 (1993-05-01), Rowe et al.
patent: 5212079 (1993-05-01), Fujio et al.
patent: 5238683 (1993-08-01), Crystal
patent: 5240694 (1993-08-01), Gwaltney, Jr.
patent: 5250425 (1993-10-01), Fujio et al.
patent: 5292773 (1994-03-01), Hirsch et al.
patent: 5310567 (1994-05-01), Nakaji et al.
patent: 5405641 (1995-04-01), Kurihara et al.
patent: 5422097 (1995-06-01), Gwaltney, Jr.
patent: 5430045 (1995-07-01), Goldberg et al.
patent: 5430064 (1995-07-01), Hirsch et al.
patent: 5455030 (1995-10-01), Ladner et al.
patent: 5463029 (1995-10-01), Dunn et al.
patent: 5464825 (1995-11-01), Anderson et al.
patent: 5492689 (1996-02-01), Gwaltney, Jr.
patent: 5516921 (1996-05-01), Weigele et al.
patent: 5532215 (1996-07-01), Lezdey et al.
patent: 5534254 (1996-07-01), Huston et al.
patent: 5541297 (1996-07-01), Hansen et al.
patent: 5554655 (1996-09-01), Thoene
Arrick, et al., "Glutathione Metabolism as a Determinant of Therapeutic Efficacy: A Review," Cancer Research, 44:4224-4232 (1984).
Bitny-Szlachto, et al., "The Estimation of Oxidized and Reduced NADP by an Enzyme Reclycling System, with Oxidized Glutathione as Hydrogen Acceptor," Acta Biochim Pol., 17:175-184 (1970).
Bloch, et al., "Glutathione-Isolation and Determination," Methods in Enzymology, 3:603-605 (Edited by Colowick and Kaplan), Published by Academic Press, Inc., New York, 1957.
Cinatl, et al., "In vitro inhibition of human cytomegalovirus replication in human foreskin fibroblasts and endothelial cells by ascorbic 2-phosphate," Antiviral Research, 27:405-418 (1995).
DeFlora, et al., "Attenuation of influenza-like symptomatology and improvement of cell-mediated immunity with long-term N-acetylcysteine treatment," Eur. Respir. J., 10:1535-1541 (1997).
Eauclaire, "Healthy Remedies Preventing Colds and Flu," Vegetarian Times, (Dec. 1996).
Han, et al., "Effect of long-term dietary," Abstract 3548 (undated), No Date.
Hennet, et al., "Alterations in antioxidant defences in lung and liver of mice infected with influenza A virus," Journal of General Virology, 73:39-46 (1992).
Hopkins, "On Glutathione: A Reinvestigation," The Journal of Biological Chemistry, vol. LXXXIV, Baltimore (1929) (Edited for the American Society of Biological Chemists by Stanley R. Benedit, et al.).
Kalebic, et al., "Suppression of human immunodeficiency virus expression in chronically infected moncytic cells by glutathione, glutathione ester, and N-acetylcysteine," Proc. Natl. Acad. Sci. USA, 88:986-990 (1991).
Meister, et al., "Glutathione," Ann. Rev. Biochem., 52:711-760 (1983).
Napier, "Nutrition Facts and Fiction About Vitamin E," Harvard Health Letter, vol. 22(1):1-3 (1996).
Ozawa, et al., "A New synthesis of Glutathione via the Thiazoline Peptide," Bull. Chem. Soc. Jpn., 53:2592-2593 (1980).
Palmara, et al., "Glutathione Directly Inhibits Late Stages of the Replication Cycle of HIV and Other Viruses," Chemotherapy, IXth International Conference on AIDS and the IVth Std. World Congress, IXth International Conference on AIDS in Affiliation with the IVth Std. World Congress, Meeting, Berlin, Germany, Jun. 6-11, 1993, 639P, IXth International Conference on AIDS, Berlin, Germany, Abstract PO-A25-0579 (1993).
Palmara, et al., "Evidence for Antiviral Acitivity of Glutathione: in Vitro Inhibition of Herpes Simplex Virus Type 1 Replication," Antiviral Res., 27(3):237-253 (1995).
Robinson, "N-Acetylcysteine," Drugs of the Future, 20/6:559-563 (1995).
Sekine, et al., "Silyk Phosphites. 21. A New Method for the Synthesis of L-Ascorbic Acid 2-O-Phosphate.sup.1 by Utilizing Phosphoryl Rearrangement," J. Org. Chem., 47:3453-3453 (1982).
Smith, et al., "2-Methyl-2-thiazoline-4-carboxylic Acid: Formation from N-Acetylcystein and Hydrolysis," J. Org. Chem., 26:820-823 (1961).
Streightoff, "In vivo Antiviral Chemotherapy: II. Anti-Influenza Action of Compounds Affecting Mucous Secretions," Antimicrobial Agents and Chemotherapy, 6:503-508 (1966).
Williamson and Meister, "Stimulation of hepatic glutathione formation by administration of L-2-oxothazolidine-4-carboxylate, a 5-oxo-L-prolinase substrate," Proc. Natl. Acad. Sci. USA, 78:936-939 (1981).
Ansel, et al., Pharmaceutical Dosage Forms and Drug Delivery Systems, published by Williams & Wilkins, A Waverly Company, Sixth Edition (1995).
Han, et al., "Effect of long-term dietary antioxidant supplementation on influenza infection," The FASEB Journal, Abstracts 1-3805 Tutorials T1-T13, Experimental Biology 97, New Orleans, Louisiana (Apr. 6-9, 1997) Abstract 3548.
The Merck Index, Eleventh Edition, p. 14 (1989).
The Merck Index, Ninth Edition, p. 579 (1976).
The Merck Index, Eleventh Editon, p. 703 (1989).
Remington's Pharmaceutical Sciences, published by Mack Publishing Company, Easton, Pennsylvania 18th Edition (1990).
"Glutathione," Biochemical Preparations, published by John Wiley & Sons, Inc., vol. 2:87-91 (1952).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Compounds and their combinations for the treatment of influenza does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Compounds and their combinations for the treatment of influenza , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compounds and their combinations for the treatment of influenza will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1462451

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.