Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2003-08-07
2011-12-27
Ha, Julie (Department: 1654)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C514S001100, C514S018400, C514S021700, C530S300000, C530S328000
Reexamination Certificate
active
08084429
ABSTRACT:
Provided are compounds represented by:wherein R1is a D-alanine, D-serine, D-threonine, D-methionine, D-leucine, D-asparagine or D-glutamine side chain and R2is a phenylalanine or tryptophan side-chain, and compositions containing such compounds.
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Lipkowski et al., “Biological Activity of Fragments and Analogues of the Potent Dimeric Opioid Peptide Biphalin,” Biorg. Med. Chem. Let., 1999, 9, 2763-6.
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Abbruscato et al., “Brain and Spinal Cord Distribution of Biphalin: Correlation with Opioid Receptor Density and Mechanism of CNS Entry,” J. Neurochem., 1997, 69, 1236-45.
Kanai et al. “Expression Cloning and Characterization of a Transporter for Large Neutral Amino Acids Activated by the Heavy Chain of 4F2 Antigen (CD98),” J. Biol. Chem., 1998, 273, 23629-32.
Lipkowski, A. W. et al. (2002) “Biological properties of a new fluorescent biphalin fragment analogue.”Life Sciences, vol. 70, No. 8, pp. 893-897.
Bonney Iwona
Carr Daniel
Kosson Dariusz
Lipkowski Andrzej
Misjecka-Kesik Aleksandra
Cooper & Dunham LLP
Gershik Gary J.
Ha Julie
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