Compounds and process for measuring c-reactive protein

Details Compounds and process for measuring c-reactive protein Compounds and process for measuring c-reactive protein

1988-06-14

1991-03-26

Shen, Cecilia

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

540452, 549208, 549220, 549349, 549351, 436 86, C07D49816, C07F 906, G01N 3300

Patent

active

050030655

ABSTRACT:
New compounds are described of the formula: ##STR1## wherein Z is selected from ##STR2## each x is selected from ##STR3## n is an integer from 1-10; each Y is selected from hydrogen, --NH.sub.2, --COQ, --COOQ, --COONHQ, --COOH, --OH, W, halogen and Q; wherein each Q is independently selected from substituted and unsubstituted lower alkenyl and lower alkyl and wherein the substitutuents are selected from --NH.sub.2 halogen, --OH, and --COOH; D is selected from hydroxy, hydrogen and --NH.sub.2 ; and W is selected from ##STR4## wherein each R is independently selected from hydrogen and lower alkyl; R' is selected from ethylene, propylene, isopropylene and phenylene; M is selected from chlorine and hydroxy; A is selected from hydrogen, lower alkyl, lower alkenyl, cycloalkyl, and phenyl; (B) is selected from ##STR5## --CO--, --NHCO--, --O--, --COO--, --N.dbd.N--, or represents a confugate bond; L.sub.1 and L.sub.2 are selected from hydroxy substituted or unsubstituted lower alkyl, cycloalkyl, lower alkenyl, or phenyl; providing L.sub.2 can be a conjugate bond. These compounds have specific utility in a process, for measuring c-reactive protein by binding with c-reactive protein and acting to release metal ions and/or inhibit the flow of the metal ion complex under electrochemically measurable conditions.

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