Compounds and peptides that bind to the erythropoietin receptor

Details Compounds and peptides that bind to the erythropoietin receptor Compounds and peptides that bind to the erythropoietin receptor

1995-06-07

1998-06-30

Jagannathan, Vasu S.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

530324, 530325, 530326, 530327, 530328, 435 691, C07K 700, C12N 1509

Patent

active

057735697

ABSTRACT:
Peptides of 10 to 40 or more amino acid residues in length and having the sequence X.sub.3 X.sub.4 X.sub.5 GPX.sub.6 TWX.sub.7 X.sub.8 (SEQ ID NO:252) where each amino acid is indicated by standard one letter abbreviation; X.sub.3 is C; X.sub.4 is R, H, L, or W; X.sub.5 is M, F, or I; X.sub.6 is independently selected from any one of the 20 genetically coded L-amino acids; X.sub.7 is D, E, I, L, or V; and X.sub.8 is C, which bind and activate the erythropoietin receptor (EPO-R) or otherwise act as an EPO agonist, and methods for their use.

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