Compounds and methods useful for the synthesis of thromboxane A.

Details Compounds and methods useful for the synthesis of thromboxane A. Compounds and methods useful for the synthesis of thromboxane A.

1985-05-30

1987-06-09

Milestone, Norma S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549363, 549269, C07D49318

Patent

active

046721312

ABSTRACT:
Compounds having the structure: ##STR1## wherein X may be hydrogen, bromine, chlorine, fluorine or iodine are provided, together with methods for synthesizing these compounds, pharmaceutical compositions and use therof for reducing vascular blood flow.
Also provided are compounds having the structure: ##STR2## wherein X may be bromine, chlorine, fluorine or iodine, together with methods for preparing the compounds, pharmaceutical compositions and use thereof for reducing vascular blood flow.

REFERENCES:
Hamberg, M. et al., Proc. Nat'l, Acad. Sci. U.S.A., 72, (1975), pp. 2994-2998.
Ito, H. et al., Carbohydr. Res., 86, (1980), pp. 193-202.
Varma, A. J. et al., J. Org. Chem., 46, (1981), pp. 799-803.
Kong, F. et al., Carbohydr. Res., 112, (1983), pp. 141-147.
Fried, J. et al., J. Am. Chem. Soc. 106, (1984), pp. 3871-3872.
Granstrom, E. et al., Prostaglandins and the Cardiovascular System, John A. Oates, Ed., Raven Press, New York, (1982), pp. 15-58.

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