Compounds and methods useful for the synthesis of thromboxane A.

Details Compounds and methods useful for the synthesis of thromboxane A. Compounds and methods useful for the synthesis of thromboxane A.

1986-10-22

1988-11-01

Robinson, Allen J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 31335

Patent

active

047820810

ABSTRACT:
Compounds having the structure: ##STR1## wherein X may be hydrogen, bromine, chlorine, fluorine or iodine are provided, together with methods for synthesizing these compounds, pharmaceutical compositions and use thereof for reducing vascular blood flow.
Also provided are compounds having the structure: ##STR2## wherein X may be bromine, chlorine, fluorine or iodine, together with methods for preparing the compounds, pharmaceutical compositions and use thereof for reducing vascular blood flow.

REFERENCES:
Hamberg, M. et al., Proc. Nat'l, Acad. Sci. U.S.A., 72, (1975), pp. 2994-2998.
Ito, H. et al., Carbohydr. Res., 86 (1980), pp. 193-202.
Varma, A. J. et al., J. Org. Chem., 46, (1981), pp. 799-803.
Kong, F. et al., Carbohydr. Res., 112 (1983), pp. 141-147.

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