Compounds and methods to treat cardiac failure and other disorde

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514321, 514323, 546198, 546199, 546201, A61K 31445, C07D40106

Patent

active

06130235&

ABSTRACT:
The invention is directed to compounds of the formula ##STR1## and the pharmaceutically acceptable salts thereof wherein Ar.sup.1 is indole, benzimidazole, or benzotriazole, optionally substituted with lower alkyl (1-4C), halo, or lower alkoxy (1-4C);

REFERENCES:
patent: 4088765 (1978-05-01), Winn et al.
patent: 4243806 (1981-01-01), Raeymaekers et al.
patent: 5462934 (1995-10-01), Goto et al.
patent: 5698553 (1997-12-01), Prucher et al.
patent: 5714498 (1998-02-01), Kulagowski et al.
Fischer "Physical chemical properties and local anesthetic results of an ether substitute of procaine" CA 67:10051, 1966.
Fischer et al. "Physical -chemical properties and local . . . " CA 67:10051, 1966.
Maguire et al. "The contribution of adenosine to the . . . " CA 92:122605, 1979.
Oelschlaeger et al. "Synthesis of new compounds with . . . " CA 109:73387, 1988.
Harbeson et al. "Inhibition of arginine aminopeptidase . . . " CA 109:162909, 1988.
Eyers, P.A. et al. "Conversion of SB 203580-insensitive MAP kinase family members to drug-sensitive forms by a single amino-acid substitution", Chem and Biol (1995) 5:321-328.
Jiang, Y. et al., "Characterization of the structure and function of a new mitogen-activated protein kinase (p38.beta.)" J Biol Chem (1996) 271:17920-17926.
Kumar, S. et al. "Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles", Biochem Biophys Res Comm (1997) 235:533-538.
Li, Z. et al. "The primary structure of p38.gamma.: a new member of p38 group of MAP kinases", Biochem Biophys Res Comm (1996) 228:334-340.
Stein, B. et al. "p38-2, a novel mitogen-activated protein kinase with distinct properties", J Biol Chem (1997) 272:19509-19517.
Wang, X.S., et al., "Molecular cloning and characterization of a novel p38 mitogen-activated protein kinase", J Biol Chem (1997) 272:23668-23674.
Wang, Y. et al. "Cardiac muscle cell hypertrophy and apoptosis induced by distinct members of the p38 mitogen-activated protein kinase family", J Biol Chem (1998) 273:2161-2168.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Compounds and methods to treat cardiac failure and other disorde does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Compounds and methods to treat cardiac failure and other disorde, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compounds and methods to treat cardiac failure and other disorde will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2257258

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.