Compounds and methods of use to derivatize neighboring lysine re

Details Compounds and methods of use to derivatize neighboring lysine re Compounds and methods of use to derivatize neighboring lysine re

1995-06-06

1997-04-15

Travers, Russell

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514265, 514275, 514641, A61K 3152

Patent

active

056209835

ABSTRACT:
The present invention concerns compounds that block the movement of viral particles through the nuclear membrane and thereby prevent the productive infection of terminally differentiated cells by virus the life cycle of which includes such an importation step. The invention encompasses methods of use of such compounds. The use of the compounds to detect certain specific protein structures which are present in nuclear localization sequences is also taught.

REFERENCES:
patent: 4782062 (1988-11-01), Tolman et al.
patent: 4879296 (1989-11-01), Daluge et al.

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