Compounds and methods of making

Details Compounds and methods of making Compounds and methods of making

1980-04-14

1982-08-31

Nucker, Christine M.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

23230B, 424 1, 424 12, 562440, 564165, C07C12300, C07C13100, G01N 3354

Patent

active

043471781

ABSTRACT:
A radioimmunoassay procedure has been discovered for bupropion [(.+-.)-2-t-butylamino-3-chloropropiophenone], an antidepressant compound, in biological fluids. Novel compounds of formula ##STR1## wherein either R.sub.2 is oxygen and R.sub.1 is (CH.sub.2).sub.n -O-(CO).sub.m -(CH.sub.2).sub.p -COOH where n is an integer from 0 to 5, m is 0 or 1, and p is an integer from 1 to 4; or R.sub.1 is hydrogen and R.sub.2 is N-O-(CH.sub.2).sub.q -COOH where q is an integer from 1 to 3, and novel methods of making them and novel intermediates useful therein are disclosed. Novel immunogens for raising bupropion specific antisera, and novel methods of making them are disclosed comprising conjugates of the novel compounds and suitable carrier material. The drug is added to the antisera together with novel radiolabeled competitor of formula ##STR2## wherein R' is a suitable radioisotope as described above and R.sub.3 is hydrogen, R.sub.4 is Cl, and R.sub.5 is oxygen, or R' is hydrogen and either

REFERENCES:
patent: 3896166 (1975-07-01), Kaiser et al.
patent: 4016202 (1977-04-01), Koppe et al.
patent: 4034103 (1977-07-01), Hartog et al.
patent: 4041076 (1977-08-01), Avenia
Findlay et al., Res. Comm. Chem. Pathol. Pharmacol., 17(4), 595-603, (1977).

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