Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof
Reexamination Certificate
2008-01-01
2008-01-01
Salimi, Ali R. (Department: 1648)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Virus or component thereof
C435S006120
Reexamination Certificate
active
10905527
ABSTRACT:
An isolated sequence or peptide isolated from an E2, E4, E6, E7 early or late coding region of human papillomavirus (HPV) that is soluble in aqueous medium, and characterized by a linkage to another protein sequence or peptide isolated from the E2, E4, E6, E7 early or late coding region of HPV by a spacer sequence, wherein the isolated protein sequence or peptide consists of more than 50% hydrophilic amino acids, and is recognized by a specific antibody of HPV. Also disclosed are isolated protein sequences or peptides from Harvey Ras (H-Ras), Kirsten Ras (K-Ras), and phosphatase and tensin homologue (PTEN) tumor suppressor proteins and Chlamydia trachomatis heat shock protein 60 (CHSP60 groEL1) and methods for detecting or diagnosing cancer or cellular abnormalities.
REFERENCES:
patent: 5855891 (1999-01-01), Lowy et al.
patent: 6228368 (2001-05-01), Gissmann et al.
patent: 6306397 (2001-10-01), Edwards et al.
patent: 6991795 (2006-01-01), Lowe et al.
patent: 7182947 (2007-02-01), Hallek et al.
Anna S. Kadish, et al: Regression of cervical intraepithelial neoplasia and loss of human papillomavirus (HPV) infection is associated with cell-mediated immune responses to an HPV type 16 E7 peptide. Cancer Epidemiology, Biomarkers & Prevention 11: 483-488, 2002.
M.Y. Tjiong, et al: Antibodies against human papillomavirus type 16 and 18 E6 and E7 protein in cericovaginal washings and serum of patients with cervical neoplasia. Viral immunology. 14: 415-424, 2001.
Ricardo Rosales, et al: Antibodies against Human Papillomavirus (HPV) Type 16 and 18 E2, E6 and E7 proteins in Sera: Correlation With Presence of Papillomavirus DNA. J Med. Virol 65: 736-744, 2001.
A. Pedroza-Saavedra, et al: high prevalence of serum antibodies to ras and type 16 E4 proteins of human papillomavirus in patients with precancerous lesions of the uterine cervix. Arch Virol 145: 603-623, 2000.
Shixuan Huang, et al: Human Papillomavirus type 52 and 58 are prevalent in cervical cancers from Chinese women, Int. J. Cancer, 70: 408-411, 1997.
Koji Matsumoto, et al: Human Papillomavirus type 16 E6 variants and HLA class II Alleles among Japanese women with cervical cancer, Int. J. Cancer, 106: 919-922, 2003.
Huang-Cheng Lai, et al: Favorable clinic outcome of cervical cancers infected with human papillomavirus type 58 and related types, Int. J. cancer, 84: 553-557, 1999.
Alba-Lucia Combita, et al: Serologic response to human oncogenic papillomavirus types 16, 18, 31, 33, 58, and 59 virus-like particles in Columbian women with invasive cervical cancer, Int. J. Cancer, 97: 796-803, 2002.
Anna Di Lonardo, et al: HPV 16 E7 antibody levels in cervical cancer patients: Before and after treatment, Journal of Medical Virology, 54: 193-195, 1998.
Tarja Anttila, et al: Serotypes of Chlamydia trachomatis and risk for development of cervical squamous cell carcinoma, JAMA, 285 (1): 2001.
Arkadiusz Chil, et al: Alternations in expression of selected HMCX antigens in premalignant lesions and squamous carcinomas of the uterine cervix, Acta Obstetricia et Gynecologia Scandinavica, 82: 1146-1152, 2003.
Lora Hedrick Ellenson, et al: Focus on endometrial and cervical cancer, Cancer Cell, 533-538, 2004.
Takeo Minaguchi, et al: Association of PTEN mutation with HPV-negative adenocarcinoma of the uterine cervix, Cancer Letters, 210: 57-62 2004.
Intellectual Property Law Group LLP
Lee Otto O.
Salimi Ali R.
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