Compounds and methods for treatment of thromboembolic disorders

Details Compounds and methods for treatment of thromboembolic disorders Compounds and methods for treatment of thromboembolic disorders

1995-03-27

1997-01-21

Jacobson, Dian C.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

424 9463, 435212, 435226, A61K 3846, A61K 3849, C12N 948, C12N 964

Patent

active

055957366

ABSTRACT:
The present invention provides derivatives of tissue plasminogen activator that lack the Finger, Growth Factor and Kringle 1 domains and comprise a Kringle 2 domain that is monoglycosylated at a site other than that of t-PA. Using recombinant DNA techniques, an alternate glycosylation sequence is provided within the Kringle 2 domain of these t-PA derivatives. This alternate glycosylation consensus sequence, as well as the glycosylation consensus sequence within the Serine Protease domain, is glycosylated upon the expression and secretion of these molecules from eucaryotic host cells. Thus, a homogeneous population of diglycosylated t-PA derivatives that lack the Finger, Growth Factor and Kringle 1 domains is produced.

REFERENCES:
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Ny,To, et al, 1954 PNAS 51:5355-5359.
Pennica, D. et al 1983 Nature 301:214-221.

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