Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Stablizing an enzyme by forming a mixture – an adduct or a...
Patent
1991-06-13
1993-12-21
Robinson, Douglas W.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Stablizing an enzyme by forming a mixture, an adduct or a...
435212, 435216, 435219, 424 941, 424 9464, C12N 996, C12N 948, C12N 970, A61K 37547
Patent
active
052720764
ABSTRACT:
The present invention provides adducts of human t-PA derivatives, which comprise a t-PA derivative that lacks the Finger, Growth Factor and Kringle 1 domains, bound to an amphipathic molecule. The invention also provides methods for preparing the adducts and compositions for the treatment of thromboembolic disorders.
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Sarmientos, et al., "Synthesis & Purification of Active Human Tissue Plasminogen Activator From Escherichia coli:", Bio/Technology, vol. 7, May. 1989, pp. 495-501.
Burck et al., 1990, J. Biological Chemistry 265:5170.
Jackson et al., 1990, Circulation 82(3):930-940.
Wilhelm et al., 1990, Thrombosis and Haemostasis 63(3):464-471.
Higgins et al., 1990, Annu. Rev. Pharmacol. Toxicol. 30:91-121.
Burck Philip J.
Zimmerman Ronald E.
Eli Lilly and Company
Larson Kristin
Plant Thomas G.
Robinson Douglas W.
Whitaker Leroy
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