Compounds and methods for treatment and diagnosis of mycobacteri

Details Compounds and methods for treatment and diagnosis of mycobacteri Compounds and methods for treatment and diagnosis of mycobacteri

1998-06-11

2000-12-12

Mosher, Mary E.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

530825, 930200, 4242481, 4242821, C07K 1435, A61K 3904

Patent

active

061600938

ABSTRACT:
The present invention provides polypeptides comprising an immunogenic portion of a M. vaccae protein and DNA molecules encoding such polypeptides, together with methods for their use in the diagnosis and treatment of mycobacterial infection. Methods for enhancing the immune response to an antigen including administration of M. vaccae culture filtrate, delipidated M. vaccae cells or delipidated and deglycolipidated M. vaccae cells are also provided.

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R.G. White et al., "Correlation of Adjuvant Activity and Chemical Structure of Wax D Fractions of Mycobacteria," Immunology 7, pp. 158-171, 1964.
R.G. White, "Characterization of Micobacterial Components of Adjuvant Mixtures," Symposium Series Immunobiol. Standard 6, pp. 49-58, 1967.
R.G. White et al., The Influence of Components of M. Tuberculosis and other Mycobacteria upon Antibody Production to Ovaibumin, Immunology I, pp. 54-66, 1958.
Skinner, Immunization with Heat-Killed Mycobacterium vaccae Stimulates CD8.sup.+ Cytotoxic T Cells Specific for Macrophages Infected with Mycobacterium tuberculosis, Infection and Immunity 65:11, 4525-4530, 1997.
Matthysse et al. Journal of Bacteriology 178 (17):5302-5308, Sep. 1996.

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