Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-09-21
1996-03-05
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
544280, A61K 31505, C07D48704
Patent
active
054968224
ABSTRACT:
The compounds of the formula, ##STR1## wherein the ring A is a pyrrole ring which may be hydrogenated; --B-- is a divalent cyclic or chain group which may be substituted; one of Q.sup.1 and Q.sup.2 is N, with the other being N or CH; W is a halogen or hydrogen atom or a group bonded to the bonding line with a carbon, nitrogen, oxygen or sulfur atom, provided that W is not --NH.sub.2 ; X is an amino, hydroxyl or mercapto group; Y is a hydrogen atom or a hydroxyl or amino group; Z is a straight-chain divalent group having a number of atoms of 2 to 5 composed of carbon atoms which each may be substituted, or carbon atoms which each may be substituted and one hetero atom which may be substituted; --COOR.sup.1 and --COOR.sup.2 each is the same as or different from the other and represents a carboxyl group which may be esterified, or salts thereof are provided.
The compounds are produced by reacting compounds of the formula, ##STR2## wherein A, --B--, W, W, X, Y, Q.sup.1 and Q.sup.2 are the same as defined above, with compounds of the formula, ##STR3## wherein --COOR.sup.1 and --COOR.sup.2 are the same as defined above, and useful as anti-tumor agents.
REFERENCES:
patent: 3024243 (1962-03-01), Song et al.
patent: 3320268 (1967-05-01), Shen
patent: 4939159 (1990-07-01), Anderson et al.
patent: 4996206 (1991-02-01), Taylor et al.
patent: 4997838 (1991-03-01), Akimoto et al.
patent: 5028608 (1991-07-01), Taylor et al.
CA 112:158968n by Akimoto et al (1990).
Journal of Medicinal Chemistry, vol. 28, 1985, pp. 914-921.
Akimoto Hiroshi
Hitaka Takenori
Shah Mukund J.
Sripada Pavanaram K.
Takeda Chemical Industries Ltd.
LandOfFree
Compounds and methods for treating tumors does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compounds and methods for treating tumors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compounds and methods for treating tumors will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1413075