Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system
Patent
1993-05-12
1997-07-15
Ivy, C. Warren
Organic compounds -- part of the class 532-570 series
Organic compounds
Four or more ring nitrogens in the bicyclo ring system
544146, 544152, 544256, 544283, 544284, 549 62, 549 66, 549 67, 549 68, 549 70, 549 71, 549 72, 549 73, 549 74, 549 75, 549 77, 549 78, 549 79, 549 80, 549473, 549475, 549476, 549477, 549478, 549480, 549483, 549484, 549487, 549488, 549491, 549492, 549494, 549496, 549497, 549498, 549499, 549500, 549501, 549502, C07D33322, C07D41300
Patent
active
056484860
ABSTRACT:
2,5-Diaryl tetrahydrofurans, 2,5-diaryl tetrahydrothiophenes, 2,4-diaryl tetrahydrofurans, 2,4-diaryl tetrahydrothiophenes, 1,3-diaryl cyclopentanes, 2,4-diaryl pyrrolidines, and 2,5-diaryl pyrrolidines are disclosed that reduce the chemotaxis and respiratory burst leading to the formation of damaging oxygen radicals of polymorphonuclear leukocytes during an inflammatory or immune response. The compounds exhibit this biological activity by acting as PAF receptor antagonists, by inhibiting the enzyme 5-lipoxygenase, or by exhibiting dual activity, i.e., by acting as both a PAF receptor antagonist and inhibitor of 5-lipoxygenase.
A method to treat disorders mediated by PAF or leukotrienes is also disclosed, that includes administering an effective amount of one or more of the above-identified compounds or a pharmaceutically acceptable salt thereof, optionally in a pharmaceutically acceptable carrier.
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Cai Xiong
Hussoin Sajjat
Hwang San-Bao
Killian David
Shen T. Y.
Covington Raymond
CytoMed, Inc.
Ivy C. Warren
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