Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1995-06-07
1999-01-05
Kight, John
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
5142372, 514333, 514337, 514435, 514445, 514448, 514471, 514472, 514473, 544174, 544176, 544180, 546256, 546283, 546284, 549 67, 549 70, 549 71, 549 72, 549 73, 549 74, 549 80, 549473, 549475, 549476, 549477, 549478, 549480, 549483, 549484, 549487, 549488, 549491, 549492, 549494, 549495, 549496, 549497, 549498, 549499, 549500, 549501, 549502, A61K 31535, A61K 4340, A61K 4308, A61K 4306
Patent
active
058563237
ABSTRACT:
2,5-Diaryl tetrahydrofurans, 2,5-diaryl tetrahydrothiophenes, 2,4-diaryl tetrahydrofurans, 2,4-diaryl tetrahydrothiophenes, 1,3-diaryl cyclopentanes, 2,4-diaryl pyrrolidines, and 2,5-diaryl pyrrolidines are disclosed that reduce the chemotaxis and respiratory burst leading to the formation of damaging oxygen radicals of polymorphonuclear leukocytes during an inflammatory or immune response. The compounds exhibit this biological activity by acting as PAF receptor antagonists, by inhibiting the enzyme 5-lipoxygenase, or by exhibiting dual activity, i. e., by acting as both a PAF receptor antagonist and inhibitor of 5-lipoxygenase.
A method to treat disorders mediated by PAF or leukotrienes is also disclosed, that includes administering an effective amount of one or more of the above-identified compounds or a pharmaceutically acceptable salt thereof, optionally in a pharmaceutically acceptable carrier.
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Cai Xiong
Hussoin Sajjat
Hwang San-Bao
Killian David
Shen T. Y.
Covington Raymond
CytoMed, Inc.
Kight John
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