Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1998-02-13
2000-02-15
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514473, 514472, 514445, 514446, 514447, 514448, 514598, 514612, 514645, 514575, A01N 4306
Patent
active
060253843
ABSTRACT:
Tetrahydrofurans, tetrahydrothiophenes, pyrrolidines and cyclopentanes are disclosed that reduce the chemotaxis and respiratory burst leading to the formation of damaging oxygen radicals of polymorphonuclear leukocytes during an inflammatory or immune response. It has been determined that 5-lipoxygenase activity, oral availability, and stability in vivo (for example, glucuronidation rate) can vary significantly among the optical isomers of the disclosed compounds.
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Communication dated Mar. 4, 1997 in European Patent App. No. 95907972.4.
Cai Xiong
Fura Aberra
Qian Changgeng
Corless Peter F.
Faulkner D.
LeukoSite, Inc.
Page Thurman K.
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