Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-05-31
1997-12-30
Ivy, C. Warren
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514336, 514397, 514428, 514438, 514473, 546283, 548153, 5483157, 548567, 549 65, 549 77, 549496, A61K 3134, C07D30716
Patent
active
057030936
ABSTRACT:
Tetrahydrofurans, tetrahydrothiophenes, pyrrolidines and cyclopentanes are disclosed that reduce the chemotaxis and respiratory burst leading to the formation of damaging oxygen radicals of polymorphonuclear leukocytes during an inflammatory or immune response. It has been determined that 5-lipoxygenase activity, oral availability, and stability in vivo (for example, glucuronidation rate) can vary significantly among the optical isomers of the disclosed compounds.
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Shen and Hu
Cai Xiong
Fura Aberra
Qian Changgeng
CytoMed, Inc.
Ivy C. Warren
Smith Lyman H.
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