Compounds and methods for the inhibition of the expression of VC

Details Compounds and methods for the inhibition of the expression of VC Compounds and methods for the inhibition of the expression of VC

1998-05-14

2000-11-14

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560138, 514548, C07C 6900, A01N 3702

Patent

active

061472506

ABSTRACT:
This invention is in the area of methods and compositions for the inhibition of the expression of VCAM-1 and, in particular, for the treatment of diseases mediated by VCAM-1, including cardiovascular and inflammatory diseases.

REFERENCES:
patent: 3179701 (1965-04-01), Rocklin
patent: 3479407 (1969-11-01), Laufer
patent: 3576883 (1971-04-01), Neuworth
patent: 3952064 (1976-04-01), Whalley
patent: 4029812 (1977-06-01), Wagner
patent: 4076841 (1978-02-01), Wagner
patent: 4078084 (1978-03-01), Wagner
patent: 4115590 (1978-09-01), Lerner
patent: 4752616 (1988-06-01), Hall
patent: 4954514 (1990-09-01), Kita
patent: 5115250 (1992-05-01), Parker
patent: 5206247 (1993-04-01), Regnier
patent: 5262439 (1993-11-01), Parthasarathy
patent: 5380747 (1995-01-01), Medford
patent: 5608095 (1997-03-01), Parker
patent: 5627205 (1997-05-01), Regnier
patent: 5750351 (1998-05-01), Medford
U.S. Serial No. 09/078,935 Medford, May 14, 1998.
Baron, J.L. et al., J. Clin. Invest. 93, 1700-1708 (1994).
Brown and Goldstein, Ann. Rev. Biochem. 52, 223 (1983).
Burkly, L.C. et al., Diabetes 43, 523-534 (1994).
Carew et al. Proc. Natl. Acad. Sci. U.S.A. 84:7725-7729 (1987).
Folkman, J. and Shing, Y., Biol. Chem. 10931-10934 (1992).
Heeg et al., Plasma Levels of Probucol in Man After Single and Repeated Oral Doses, La Nouvelle Presse Medicale, 9(40) (1980).
Iademarco, M.F. et al., J. Biol. Chem. 267, 16323-16329 (1992).
Kazuya et al. J. Lipid Res. 32; 197-204 (1991).
Koch, A.E. et al. Lab. Invest. 64, 313-322 (1991).
Miller, Ann. Rev. Med. 31,97 (1980).
Morales-Ducret, J. et al., Immunol. 149, 1421-1431 (1992).
Ohkawara, Y., et al., Am. j. Respir. Cell Mol. Biol. 12,4-12 (1995).
Oroez, C.G. et al., Immunol. Lett. 32, 7-12 (1992).
Parthasarathy, S. et al., Probucol Inhibits Oxifative Modification of Low Density Lipoprotein, J. Clin. Invest., 77 641-644 (1986).
Patton et al., Clin. Chem. 29, 1980 (1983).
Pilewski, J.M., et al , Am. J. Respir. Cell Mol. Biol. 12, 1-3 (1995).
Rabb, A. et al., Am J. Respir. Care Med. 149, 1186+1191 (1994).
Yang, X.D. et al., Proc. Natl. Acad. Sci. U.S.A. 90,, 10494-10498 (1993.
Chemical Abstracts 127:75973, 1996.
Chemical Abstracts 82:86196, 1975.
Chemical Abstracts 126:277465, 1997.
Chemical Abstracts 94:30290, 1980.
Chemical Abstracts 86:5066, 1977.
Chemical Abstracts 122:187387, 1995.
Chemical Abstracts 124:8690, 1996.
Chemical Abstracts 124:146082, 1995.
Chemical Abstracts 110:212254, 1989.

Affiliated with

Also associated with

Rating

Compounds and methods for the inhibition of the expression of VC does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Compounds and methods for the inhibition of the expression of VC, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compounds and methods for the inhibition of the expression of VC will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2066849