Compounds and methods for modulating tissue permeability

Details Compounds and methods for modulating tissue permeability Compounds and methods for modulating tissue permeability

1998-12-29

2000-08-29

Davenport, Avis M.

Chemistry: analytical and immunological testing

Involving antibody fragments

436 63, 436 86, 530300, 530317, 530324, 530325, 530326, 530327, 530328, 530329, 530330, G01N 33563

Patent

active

061107476

ABSTRACT:
Methods for using modulating agents to enhance or inhibit occludin-mediated cell adhesion in a variety of in vivo and in vitro contexts are provided. Within certain embodiments, the modulating agents may be used to increase vasopermeability. The modulating agents comprise at least one occludin cell adhesion recognition sequence or an antibody or fragment thereof that specifically binds the occludin cell adhesion recognition sequence. Modulating agents may additionally comprise one or more cell adhesion recognition sequences recognized by other adhesion molecules. Such modulating agents may, but need not, be linked to a targeting agent, drug and/or support material.

REFERENCES:
Jaeger et al., "Small Synthetic Peptides Homologous To Segments Of Occludin Impair Tight Junction Resealing In A Ca.sup.+2 Switch Assay In A A6 Cell Monolayers," Mol. Biol. Cell. (Suppl.): p. 205A, Abstract No. 1189, 1997.
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Wong and Gumbiner, "A Synthetic Peptide Corresponding to the Extracellular Domain of Occludin Perturbs the Tight Junction Permeability Barrier," Journal of Cell Biology 136(2): 399-409, 1997.
Ando-Akatsuka et al., "Interspecies Diversity of the Occludin Sequence: cDNA Cloning of Human, Mouse, Dog, and Rat-Kangaroo Homologues," The Journal of Cell Biology 133(1): 43-47, 1996.
Chen et al., "COOH Terminus of Occludin Is Required for Tight Junction Barrier Function in Early Xenopus Embryos," The Journal of Cell Biology 138(4): 891-899, 1997.
Furuse et al., "Overexpression of occludin, a tight junction-associated integral membrane protein, induces the formation of intracellular multilamellar bodies bearing tight junction-like structures," Journal of Cell Science 109: 429-435, 1996.
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