Compounds and methods for modulating cell adhesion

Details Compounds and methods for modulating cell adhesion Compounds and methods for modulating cell adhesion

2005-11-22

2005-11-22

Tate, Christopher (Department: 1654)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Cyclic peptides

C514S009100, C514S011400

Reexamination Certificate

active

06967238

ABSTRACT:
Cyclic peptides comprising a cadherin cell adhesion recognition sequence HAV, and compositions comprising such cyclic peptides, are provided. Methods for using such peptides for modulating cadherin-mediated cell adhesion in a variety of contexts are also provided.

REFERENCES:
patent: 5231082 (1993-07-01), Schasteen
patent: 5352667 (1994-10-01), Lider et al.
patent: 5510628 (1996-04-01), Georger, Jr. et al.
patent: 5585351 (1996-12-01), Ranscht
patent: 5591432 (1997-01-01), Bronson et al.
patent: 5646250 (1997-07-01), Suzuki
patent: 5665590 (1997-09-01), Yang
patent: 6031072 (2000-02-01), Blaschuk et al.
patent: 6169071 (2001-01-01), Blaschuk et al.
patent: 6207639 (2001-03-01), Blaschuk et al.
patent: 406 428 (1991-01-01), None
patent: WO 91/04745 (1991-04-01), None
patent: WO 92/08731 (1992-05-01), None
patent: WO 94/11401 (1994-05-01), None
patent: WO 96/40781 (1996-12-01), None
patent: WO 97/07209 (1997-02-01), None
patent: WO 98/02452 (1998-01-01), None
patent: WO 98/45319 (1998-10-01), None
Alexander et al., “N-Cadherin-Like Protein Contributes to Solute Barrier Maintenance in Cultured Endothelium,”Journal of Cellular Physiology156:610-618, 1993.
Ali et al., “Conformationally Constrained Peptides and Semipeptides Derived from RGD as Potent Inhibitors of the Platelet Fibrinogen Receptor and Platelet Aggregation,”J. Med. Chem. 37(6):769-780, 1994.
Beesley et al., “The post-synaptic density: putative involvement in synapse stabilization via cahderins and covalent modification by ubiquitination,”Biochemical Society Transactions23:59-64, 1995.
Blakemore, “Remyelination of CNS axons by Schwann cells transplanted from the sciatic nerve,”Nature266:68-69, 1977.
Blaschuk and Farookhi, “Estradiol Stimulates Cadherin Expression in Rat Granulosa Cells,”Developmental Biology136:564-567, 1989.
Blaschuk et al., “E-Cadherin, estrogens and cancer: is there a connection?”The Canadian Journal of Oncology4(4):291-301, 1994.
Blaschuk et al., “Identification of a Cadherin Cell Adhesion Recognition Sequence,”Developmental Biology139:227-229, 1990.
Blaschuk et al., “Identification of a Conserved Region Common to Cadherins and Influenza Strain A Hemagglutinins,”J. Mol. Biol. 211:679-682, 1990.
Bottenstein and Sato, “Growth of a rat neuroblastoma cell line in serum-free supplemented medium,”Proc.Natl. Acad. Sci. USA76(1):514-517, 1979.
Brecknell et al., “Bridge grafts of Fibroblast Growth Factor-4-Secreting Schwannoma Cells Promote Functional Axonal Regeneration in the Nigrostriatal Pathway of the Adult Rat,”Neuroscience74(3):775-784 1996.
Brockes et al., “Studies on Cultured Rat Schwann Cells. I. Establishment of Purified Populations from Cultures of Peripheral Nerve,”Brain Research165:104-118, 1979.
Brook et al., “Morphology and Migration of Cultured Schwann Cells Transplanted Into the Fimbria and Hippocampus in Adult Rats,”GLIA9:292-304, 1993.
Byers et al., “Fibroblast Growth Factor Receptors Contain a Conserved HAV Region Common to Cadherins and Influenza Strain A Hemagglutinins: A Role in Protein-Protein Interactions?, ”Developmental Biology152:411-414, 1992.
Cardarelli et al., “The Collagen Receptorα3β1, from MG-63 and HT1080 Cells, Interacts with a Cyclic RGD Peptide,”The Journal of Biological Chemistry267(32):23159-23164, 1992.
Carlstedt et al., “Nerve Fibre Regeneration Across the PNS-CNS Interface at the Root-Spinal Cord Junction,”Brain Research Bulletin22:93-102, 1989.
Cepek et al., “Expression of a candidate cadherin in T lymphocytes,”Proc. Natl. Acad. Sci. USA93:6567-6571, 1996.
Chuah et al., “Differentiation and survival of rat olfactory epithelial neurons in dissociated cell culture,”Developmental Brain Research60: 123-132, 1991.
Craig et al., “Concept and Progress in Development of RGD-Containing Peptide Pharmaceuticals, ”Biopolymers (Peptide Science)37:157-175, 1995.
Doherty and Walsh, “CAM-FGF Receptor Interactions: A Model for Axonal Growth,”Molecular and Cellular Neuroscience8(Article No. 0049):99-111, 1996.
Doherty and Walsh, “Signal transduction events underlying neurite outgrowth stimulated by cell adhesion molecules,”Current Opinion in Neurobiology4:49-55, 1994.
Doherty and Walsh, “Neurite Outgrowth in Response to Transfected N-CAM and N-Cadherin Reveals Fundamental Differences in Neuronal Responsiveness to CAMS,”Neuron6:247-258, 1991.
Duncan et al., “Transplantation of oligodendrocytes and Schwann cells into the spinal cord of the myelin-deficient rat,”Journal of Neurocytology17:351-361, 1988.
Fok-Seang et al., “An analysis of astrocytic cell lines with different abilities to promote axon growth,”Brain Researchl689:207-223, 1995.
Fok-Seang et al., “Migration of Oligodendrocyte Precursors on Astrocytes and Meningeal Cells,”Developmental Biology171:1-15, 1995.
Franz, “Percutaneous Absorption. On The Relevance Of In Vitro Data,”The Journal of Investigative Dermatology64(3):190-195, 1975.
Franz, “The Finite Dose Technique as a Valid in Vitro Model for the Study of Percutaneous Absorption in Man,”Curr. Probl. Dermatol. 7:58-68, 1978.
Ghimikar and Eng, “Astrocyte-Schwann Cell Interactions in Culture,”GLIA11:367-377, 1994.
Gumbiner et al., “The Role of the Cell Adhesion Molecule Uvomorulin in the Formation and Maintenance of the Epithelial Junctional Complex,”The Journal of Cell Biology107:1575-1587, 1988.
Iruela-Arispe et al., “Expression of SPARC during Development of the Chicken Chorioallantoic Membrane: Evidence for Regulated Proteolysis in Vivo,”Molecular Biology of the Cell6: 327-343, 1995.
Laird et al., “Gap Junction Turnover, Intracellular Trafficking, and Phosphorylation of Connexcin43 in Brefeldin A-treated Rat Mammary Tumor Cells,”The Journal of Cell Biology131(5):1193-1203, 1995.
Lee et al., “Expression of the Homotypic Adhesion Molecule E-Cadherin by Immature Murine Thymocytes and Thymic Epithelial Cells,”Journal of Immunology152:5653-5659, 1994.
Letourneaur et al., “Interactions of Schwann Cells with Neurites and with Other Schwann Cells Involve the Calcium-dependent Adhesion Molecule, N-cadherin,”Journal of Neurobiology22(7):707-720, 1991.
Liuzzi and Lasek , “Astrocytes Block Axonal Regeneration in Mammals by Activating the Physiological Stop Pathway,”Science237:642-645, 1987.
Lutz et al., “Secondary Structure of the HAV Peptide Which Regulates Cadherin-Cadherin Interaction,”Journal of Biomolecular Structure & Dynamics13(3):447-455, 1995.
Matsuzaki et al., “cDNAs of Cell Adhesion Molecules of Different Specificity Induce Changes in Cell Shape and Border Formation in Cultured S180 Cells,”The Journal of Cell Biology110:1239-1252, 1990.
McCarthy and Vellis, “Preparation of Separate Astroglial and Oligodendroglial Cell Cultures from Rat Cerebral Tissue,”J. Cell Biology85:890-902, 1980.
Mege et al., “Construction of epithelioid sheets by transfection of mouse sarcoma cells with cDNAs for chicken cell adhesion molecules,”Proc. Natl. Acad. Sci. USA85:7274-7278, 1988.
Moran, “The Protein Delivery Service. Advances in technologies for delivering proteins and peptides in therapeutically useful forms,”Pharmaceutical Forum Issue6:4-7, 1996.
Munro and Blaschuk,Cell Adhesion and Invasion in Cancer Metastasis, R.G. Landes Company, Austin, TX, 1996, Chapter 3, “The Structure, Function and Regulation of Cadherins,” pp. 17-34.
Munro et al., “Characterization of Cadherins Expressed by Murine Thymocytes,”Cellular Immunology169(Article No. 0123):309-312, 1996.
Newton et al., “N-Cadherin Mediates Sertoli Cell-Spermatogenic Cell Adhesion,”Developmental Dynamics197:1-13, 1993.
Nose et al., “Localizatio

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