Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-12-15
2010-06-29
Shiao, Rei-tsang (Department: 1628)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S365000, C514S423000, C548S530000, C548S200000, C546S245000
Reexamination Certificate
active
07745464
ABSTRACT:
The present invention relates to heterocyclic compounds that bind to Bcl proteins and inhibit Bcl function, compositions comprising such compounds, and methods for treating and modulating disorders associated with hyperproliferation, such as cancer.
REFERENCES:
patent: 6747050 (2004-06-01), Kim et al.
patent: 2004/0147473 (2004-07-01), Warrell
patent: 2005/0032714 (2005-02-01), Warrell
patent: 2006/0025460 (2006-02-01), Castro et al.
patent: 2006/0199817 (2006-09-01), Tasker et al.
patent: 2008/0293731 (2008-11-01), Feuerbach et al.
patent: 2009/0133319 (2009-05-01), Lahm et al.
patent: 0 970 950 (2000-01-01), None
patent: WO 02/17852 (2002-03-01), None
patent: WO 02/097053 (2002-12-01), None
patent: WO 03/015788 (2003-02-01), None
patent: WO 2006/009869 (2006-01-01), None
patent: WO 2007/068476 (2007-06-01), None
patent: WO 2007/075459 (2007-07-01), None
Kuramochi et al., 2004, CAS: 142: 74358.
Tanaka et al., 1991, CAS: 114: 81225.
Carboni et al. CAS: 141:360665.
Tasker et al., 2006, CAS: 145: 315004.
Dong et al., 2005, CAS: 143:153230.
Pulley, H. et al., “Small-molecule inhibitors of Bcl-2 protein”,Drugs Fut.,29(4):369-381 (Prous Science)(2004).
International Search Report dated Jun. 12, 2007.
Baell, J.B., et al. “Prospects for Targeting the BCL-2 Family of Proteins to Develop Novel Cytotoxic Drugs.”Biochemical Pharmacology64: 851-863 (2002).
Ding, X. et al. “Catalytic Asymmetric 1,3-Dipolar Cycloaddition of a Nitrone Bearing a Bulky Amide Moiety to gamma-Substituted Allylic Alcohols.”Chemistry Letters2002: 302-303 (2002).
Akmanova, N. A. et al. “Dipolar Addition to Carbamoyl Nitrones.”Journal of Organic Chemistry of the USSR15(10):1863-1866 (1979).
Ratts, K. W. et al. “Chemistry of Resonance Stabilized Sulfonium Ylids.”Journal of Organic Chemistry31(6): 1689-1693 (1966).
Oltersdorf, T. et al. “An Inhibition of BCL-2 Family Proteins Induces Regression of Solid Tumors.”Nature435: 677-681 (2005).
Castro Alfredo C.
Grogan Michael J.
Holson Edward B.
Hopkins Brian T.
Koney Nii O.
Foley & Hoag LLP
Shiao Rei-tsang
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