Compounds and methods for inhibiting the interaction between...

Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Binds antigen or epitope whose amino acid sequence is...

Reexamination Certificate

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C514S009100, C514S013800, C514S014800, C514S015800, C514S016700, C514S017400, C530S317000, C530S326000, C530S327000, C530S328000, C530S329000, C530S330000, C530S387900

Reexamination Certificate

active

07063842

ABSTRACT:
Modulating agents for inhibiting an interaction between α-catenin and β-catenin are provided. The modulating agents comprise one or more of: (a) a β-catenin HAV motif; (b) a peptide analogue or mimetic of a β-catenin HAV motif; or (c) an antibody or antigen-binding fragment thereof that specifically binds to a β-catenin HAV motif. Methods for using such modulating agents for inhibiting cadherin-mediated cell adhesion in a variety of contexts are also provided.

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