Compounds and methods for inhibiting selectin-mediated function

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S054000, C536S017500, C536S017600, C536S118000, C536S122000, C536S123000, C536S123100

Reexamination Certificate

active

07060685

ABSTRACT:
Compounds and methods are provided for modulating in vitro and in vivo processes mediated by selectin binding. More specifically, selectin modulators and their use are described, wherein the selectin modulators that modulate (e.g., inhibit or enhance) a selectin-mediated function comprise a class of compounds termed BASAs (Benzyl Amino Sulfonic Acids, which include a portion or analogue thereof) linked to a carbohydrate or glycomimetic.

REFERENCES:
patent: 4471057 (1984-09-01), Koprowski et al.
patent: 4851511 (1989-07-01), Hakomori et al.
patent: 4859769 (1989-08-01), Karlsson et al.
patent: 4876199 (1989-10-01), Hakomori
patent: 4925796 (1990-05-01), Bergh et al.
patent: 4946830 (1990-08-01), Pulverer et al.
patent: 5143712 (1992-09-01), Brandley et al.
patent: 5151360 (1992-09-01), Handa et al.
patent: 5211937 (1993-05-01), Brandley et al.
patent: 5268364 (1993-12-01), Kojima et al.
patent: 5304640 (1994-04-01), Lasky et al.
patent: 5352670 (1994-10-01), Venot et al.
patent: 5369096 (1994-11-01), Yamada et al.
patent: 5412123 (1995-05-01), Rao et al.
patent: 5444050 (1995-08-01), Kogan et al.
patent: 5464778 (1995-11-01), Cummings et al.
patent: 5464815 (1995-11-01), Chamow et al.
patent: 5470843 (1995-11-01), Stahl et al.
patent: 5484891 (1996-01-01), Lasky et al.
patent: 5486536 (1996-01-01), Ward et al.
patent: 5519008 (1996-05-01), Rao et al.
patent: 5527785 (1996-06-01), Bevilacqua et al.
patent: 5538724 (1996-07-01), Butcher et al.
patent: 5559103 (1996-09-01), Gaeta et al.
patent: 5576305 (1996-11-01), Ratcliffe
patent: 5580858 (1996-12-01), Ippolito et al.
patent: 5580862 (1996-12-01), Rosen et al.
patent: 5589465 (1996-12-01), Ishida et al.
patent: 5604207 (1997-02-01), DeFrees et al.
patent: 5618785 (1997-04-01), Heavner et al.
patent: 5622937 (1997-04-01), Kogan et al.
patent: 5639734 (1997-06-01), Esko et al.
patent: 5646123 (1997-07-01), Ippolito et al.
patent: 5646248 (1997-07-01), Sawada et al.
patent: 5648344 (1997-07-01), Brandley et al.
patent: 5654282 (1997-08-01), Tang et al.
patent: 5654412 (1997-08-01), Srivastava et al.
patent: 5658880 (1997-08-01), Dasgupta et al.
patent: 5663151 (1997-09-01), Martel et al.
patent: 5679321 (1997-10-01), Dasgupta et al.
patent: 5679644 (1997-10-01), Rao et al.
patent: 5686426 (1997-11-01), Martel et al.
patent: 5693621 (1997-12-01), Toepfer et al.
patent: 5695752 (1997-12-01), Rosen et al.
patent: 5710023 (1998-01-01), Collins et al.
patent: 5710123 (1998-01-01), Heavner et al.
patent: 5723583 (1998-03-01), Seed et al.
patent: 5728685 (1998-03-01), Abbas et al.
patent: 5739300 (1998-04-01), Toepfer et al.
patent: 5747463 (1998-05-01), Marinier et al.
patent: 5750508 (1998-05-01), Dasgupta et al.
patent: 5753617 (1998-05-01), Heavner et al.
patent: 5753631 (1998-05-01), Paulson et al.
patent: 5763413 (1998-06-01), Numata et al.
patent: 5763582 (1998-06-01), Rao et al.
patent: 5789385 (1998-08-01), Anderson et al.
patent: 5789573 (1998-08-01), Baker et al.
patent: 5795958 (1998-08-01), Rao et al.
patent: 5811404 (1998-09-01), De Frees et al.
patent: 5811405 (1998-09-01), Toepfer et al.
patent: 5817742 (1998-10-01), Toepfer et al.
patent: 5827817 (1998-10-01), Larsen et al.
patent: 5827837 (1998-10-01), Bevilacqua et al.
patent: 5830871 (1998-11-01), Wong et al.
patent: 5837689 (1998-11-01), Anderson et al.
patent: 5837690 (1998-11-01), Rao et al.
patent: 5840679 (1998-11-01), Larsen et al.
patent: 5854218 (1998-12-01), DeFrees
patent: 5858983 (1999-01-01), Seed et al.
patent: 5858994 (1999-01-01), Kretzschmar et al.
patent: 5880091 (1999-03-01), Cummings et al.
patent: 5916910 (1999-06-01), Lai
patent: 5919768 (1999-07-01), Korgan et al.
patent: 5919769 (1999-07-01), Tsukida et al.
patent: 5962422 (1999-10-01), Nagy et al.
patent: 5976540 (1999-11-01), Rittershaus et al.
patent: 5977080 (1999-11-01), Rosen et al.
patent: 5985852 (1999-11-01), Nagy et al.
patent: 5994402 (1999-11-01), Rotstein et al.
patent: 6001819 (1999-12-01), Simon et al.
patent: 6001988 (1999-12-01), Parma et al.
patent: 6033665 (2000-03-01), Yednock et al.
patent: 6037333 (2000-03-01), Panjwani
patent: 6110897 (2000-08-01), Unverzagt et al.
patent: 6111065 (2000-08-01), Heavner et al.
patent: 6120751 (2000-09-01), Unger
patent: 6121233 (2000-09-01), Magnani et al.
patent: 6124267 (2000-09-01), McEver et al.
patent: 6133239 (2000-10-01), Handa et al.
patent: 6133240 (2000-10-01), Taylor et al.
patent: 6136790 (2000-10-01), Toepfer et al.
patent: 6169077 (2001-01-01), Oehrlein
patent: 6177547 (2001-01-01), Cummings et al.
patent: 6187754 (2001-02-01), Oehrlein
patent: 6193973 (2001-02-01), Tuttle
patent: 6193979 (2001-02-01), Rittershaus et al.
patent: 6197752 (2001-03-01), Schmidt et al.
patent: 6225071 (2001-05-01), Cummings et al.
patent: 6235309 (2001-05-01), Nagy et al.
patent: 6280932 (2001-08-01), Parma et al.
patent: 6309639 (2001-10-01), Cummings et al.
patent: 6387884 (2002-05-01), Magnani et al.
patent: 6391857 (2002-05-01), Magnani et al.
patent: 6407135 (2002-06-01), Lai et al.
patent: 6465434 (2002-10-01), Magnani et al.
patent: 6492332 (2002-12-01), Demopulos et al.
patent: 6503885 (2003-01-01), Kiso et al.
patent: 6528487 (2003-03-01), Heavner et al.
patent: 2001/0046970 (2001-11-01), Nagy et al.
patent: 2001/0051370 (2001-12-01), Bistrup et al.
patent: 2002/0026033 (2002-02-01), Cummings et al.
patent: 2002/0028205 (2002-03-01), Holgersson et al.
patent: 2002/0031508 (2002-03-01), Wagner et al.
patent: 2002/0040008 (2002-04-01), Wagner et al.
patent: 2002/0132220 (2002-09-01), Berens et al.
patent: 2002/0164336 (2002-11-01), Harrison et al.
patent: 2002/0164748 (2002-11-01), Bistrup et al.
patent: 2002/0168366 (2002-11-01), Stewart et al.
patent: 2003/0012787 (2003-01-01), Ashkenazi et al.
patent: 2003/0012790 (2003-01-01), Ashkenazi et al.
patent: 2003/0018181 (2003-01-01), Larsen et al.
patent: 2003/0039683 (2003-02-01), Cantrell et al.
patent: 319253 (1989-06-01), None
patent: 381 310 (1990-08-01), None
patent: 408 859 (1991-01-01), None
patent: 671407 (1995-09-01), None
patent: WO 90/13300 (1990-11-01), None
patent: WO 91/19502 (1991-12-01), None
patent: WO 92/01718 (1992-02-01), None
patent: WO 92/07572 (1992-05-01), None
patent: WO 94/26760 (1994-11-01), None
patent: WO 94/29477 (1994-12-01), None
patent: WO 95/03059 (1995-02-01), None
patent: WO 95/29681 (1995-11-01), None
patent: WO 96/20204 (1996-07-01), None
patent: WO 96/25418 (1996-08-01), None
patent: WO 96/26950 (1996-09-01), None
patent: WO 97/01335 (1997-01-01), None
patent: WO 97/01569 (1997-01-01), None
patent: WO 97/14707 (1997-04-01), None
patent: WO 97/28173 (1997-08-01), None
patent: WO 97/28174 (1997-08-01), None
patent: WO 99/42130 (1999-08-01), None
patent: WO 99/43353 (1999-09-01), None
patent: WO 99/43356 (1999-09-01), None
patent: WO 02/22820 (2002-03-01), None
patent: WO 02/062810 (2002-08-01), None
Scharfman, A. et al., “Recognition of Lewis x Derivatives Present on Mucins by Flagellar Components ofPseudomonas aeruginosa,” Infection and Immunity 69(9): 5243-5248, Sep. 2001.
Scharfman, A. et al., “Pseudomonas aeruginosabinds to neoglycoconjugates bearing mucin carbohydrate determinants and predominantly to sialyl-Lewis x conjugates,”Glycobiology 9(8): 757-764, 1999.
Sprengard, U. et al., “Synthesis and Biological Activity of Novel Sialyl-LewisxConjugates,”Bioorganic&Medicinal Chemistry Letters 6(5): 509-514, 1996.
Thoma, G. et al., “Synthesis and Biological Evaluation of a Sialyl Lewis X Mimic with Significantly Improved E-selectin Inhibition,”Bioorganic&Medicinal Chemistry Letters 11:923-925, 2001.
Waldmann, H. et al., “Synthesis of 2-Acetamindo-2-Deoxyglucosylasparagine Glyco-Tripeptide and —Pentapeptides By Selective C- and N-Terminal Elongation of the Peptide Chain,”Carbohydrate Research 196:75-93, 1990.
Yamazaki, F. et al., “Syntheisis of an appropriately protected core glycotetraoside, a key intermediate for the synthesis of ‘bisected’ complex-type glycans of a glycoprotein,”Carbohydrate Research 201:15-30, 1990.
Jentsch, K.D. et al.,

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Compounds and methods for inhibiting selectin-mediated function does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Compounds and methods for inhibiting selectin-mediated function, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compounds and methods for inhibiting selectin-mediated function will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3628783

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.