Compounds and methods for inhibiting hyper-proliferative cell gr

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...

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558391, 558392, A61K 3141, C07C25500

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active

057212775

ABSTRACT:
The present invention features compounds and methods for inhibiting hyper-proliferative cell growth. The compounds and method are preferably used to treat patients having a hyper-proliferative cell disorder.

REFERENCES:
patent: 4087535 (1978-05-01), Heubach et al.
patent: 4284786 (1981-08-01), Kammerer et al.
patent: 4351841 (1982-09-01), Kammerer et al.
patent: 4992271 (1991-02-01), Fernandez et al.
patent: 5217999 (1993-06-01), Levitzki et al.
patent: 5268382 (1993-12-01), Bartlett et al.
patent: 5314685 (1994-05-01), Tyle et al.
patent: 5476866 (1995-12-01), Kuo et al.
patent: 5506249 (1996-04-01), Kuo et al.
patent: 5532259 (1996-07-01), Bartlett et al.
Kaur, "Tyrphostin induced growth inhibition: correlation with effect on p210.sup.bcr-abl autokinase activity in K562 chronic myelogenous leukemia," Anti-Cancer Drugs 5:213-222 (1994).
Kovalenko et al., "Selective Platelet-derived Growth Factor Receptor Kinase Blockers Reverse sis-Transformation," Cancer Research 54:6106-6114 (1994).
Mattar et al., "Effects of leflunomides active metabolite, A771726, on signal transduction pathways necessary for proliferation," Immunobiology 186(1-2):43 (1992) (abstract).
Borisevich et al., "Reactions of arylamides of a hydroxylamine and substituted hydrazines," Chemical Abstracts 107(7):726 at abstract No. 58919a (1987).
Borisevich et al., "Reactions of arylamides of a hydroxylamine and substituted hydrazines," Ukr. Khim. Zh. 52(6):641-647 (1986).
Kunzek et al., "Oxydationreaktionen von .alpha.-Benzoyl-.alpha.-cyan thoacetanilid," Zeitschrift Fur Chemi 15(4):145-146 (1975).
Rudorf et al., "Alkylierungs-Und Arylierungsreaktionen Mit eminalen Dithiolaten," Phosphorous and Sulfur 9(3):329-336 (1981).
Sjogren et al., "Synthesis and Biological Activity of a Series of Diaryl-Substituted .alpha.-Cyano-.beta.-hydroxypropenamides, a New Class of Anthelmintic Agents," J. Med. Chem. 34:3295-3301 (1991).
Andrews et al. (American Veterinary Medicine Association Panel on Euthanasia), "1993 Report of the AVMA Panel on Authanasia," J. American Veterinary Medicine Association, 202(2):229-249 (1993).
Axton et al., "Novel Immunosuppressive Butenamides," J. Chem. Soc. Perkin Trans. pp. 2203-2213 (1992).
Bartlett et al., "Leflunomide (HWA 486), a novel immunomodulating compound for the treatment of autoimmune disorders and reactions leading to transplantation rejection," Agents and Actions 32:10-21 (1991).
Bartlett et al., "Effects of lefluonomide on immune responses and models of inflammation," Springer Semin. Immunopathol. 14:381-394 (1993).
Bartlett et al., "Leflunomide: A novel immunomodulating drug" in Nonsteroidal Anti-Inflammatory Drugs 2nd ed. pp. 349-366, Lewis and Fursik eds., Dekker, NY NY (1990).
Baselga et al., "Antitumor Effects of Doxorubicin in Combination With Anti-epidermal Growth Factor Receptor Monoclonal Antibodies," J. of Natl. Cancer Institute 85(16):1327-1333 (1993).
Baudy et al., "Potent Quinoxaline-Spaced Phosphono .alpha.-Amino Acids of the AP-6 Type as Competitive NMDA Antagonists: Synthesis and Biological Evaluation," J. Med. Chem. 36:331-342 (1993).
Bilder et al., "Tyrphostins inhibit PDGF-induced DNA synthesis and associated early events in smooth muscle cells," Am. J. Physiol. 260(Cell Physiol.29):C721-C730 (1991).
Birchall et al., "Compositions for killing internal parasites containing 3-teri-alkyl-4-hydroxy-5-halobenzylidene-malononitriles," Chemical Abstracts 88:104957a (1978).
Bryckaert et al., "Inhibition of Platelet-Derived Growth Factor-Induced Mitogenesis and Tyrosine Kinase Activity in Cultured Bone Marrow Fibroblasts by Tyrphostins," Exp. Cell Research 199:255-261 (1992).
Bustelo and Barbacid, "Tyrosine Phosphorylation of the vav Proto-Incogene Product in Activated B Cells," Science 256:1196-1199 (1992).
Caraglia et al., "Cytosine arabinoside increases the binding of .sup.125 I-labelled epidermal growth factor and .sup.125 I-transferrin and enhances the in vitro targeting of human tumour cells with anti-(growth factor receptor)mAb," Cancer Immunol. Immunother. 37:150-156 (1993).
Carboni et al., "Cyanocarbon Chemistry. XI. Malononitrile Dimer," J. Am. Chem. Soc. 80:2838-2840 (1958).
Cecil Textbook of Medicine, eds. Wyngaarden, Smith, Bennett, W.B. Saunders (1992) p. 2220.
Chen and Okayama, "Calcium Phosphate-Mediated Gene Transfer: A Highly Efficient Transfection System for Stably Transforming Cells with Plasmid DNA," BioTech. 6:632-638 (1988).
Cherwinski et al., "The Immunosuppressant Leflunomide Inhibits Lymphocyte Progression Through Cell Cycle by a Novel Mechanism," J. Pharmacology and Exp. Therap. 272:460-468 (1995).
Chong et al., "Leflunomide, a Novel Immunosuppressive Agent," Transplantation 55:1361-1366 (1993).
Chong et al., "Leflunomide, a Novel Immunomodulatory Agent: In Vitro Analyses of the Mechanism of Immunosupression," Transplant. Proc. 25:747-749 (1993).
Conn et al., "Purification of a glycoprotein vascular endothelial cell mitogen from a rat glimo-derived cell line," Proc. Natl. Acad. Sci. USA 87:1323-1327 (1990).
Decker and Lohmann-Matthes, "A quick and simple method for the quantitation of lactate dehydrogenase release in measurements of cellular cytotoxicity and tumor necrosis factor (TNF) activity," J. Immunol. Methods 115:61-69 (1988).
Ehrlich and Bogert, "Experiments in the Veratrole and Quinoxaline Groups," J. Org. Chem. 12:522 (1947).
Ferris et al., "Synthesis of Zuinazoline Nucleosides from Ribose and Anthranilonitrile. Application of Phase-Transfer Catalysis in Nucleosides Synthesis," J. Org. Chem. 44(2):173-178 (1979).
Floege et al., "Factors involved in the regulation of mesangial cell proliferation in vitro and in vivo," Kidney International 43S:47-54 (1993).
Fry et al., "New insights into protein-tyrosine kinase receptor signaling complexes," Protein Science 2:1785-1797 (1993).
Gazit et al., "Tyrphostins. 1. Synthesis and Biological Activity of Protein Tyrosine Kinase Inhibitors," J. Med. Chem. 32:2344-2352 (1989).
Gazit et al., "Tyrphostins. 2. Heterocyclic and .alpha.-Substituted Benzylidenemalononitrile Tyrphostins as Potent Inhibitors of EGF Receptor and ErbB2
eu Tyrosine Kinases," J. Med. Chem. 34:1896-1907 (1991).
Gazit et al., "Tyrphostins. 3. Structure-Activity Relationship Studies of a .alpha.-Substituted Benzylidenemalononitrile 5-S-Aryltyrphostins" J. Med. Chem. 36:3556-3564 (1993).
Glant et al., "Immunodulation of proteoglycan-induced progressive polyarthritis by leflunomide," Immunopharmacology 23:105-116 (1992).
Gottardis et al., "Estradiol-Stimulated Growth of MCF-7 Tumors Implanted in Athymic Mice: A Model to Study the Tumoristatic Action of Tamoxifen," J. Steroid Biochem. 30(1-6):311-314 (1988).
Gulbins et al., "Tyrosine Kinase-Stimulated Guanine Nucleotide Exchange Activity of Vav in T Cell Activation," Science 260:822-825 (1993).
Hale et al., "Prognostic value of epidermal growth factor receptor expression in cervical carcinoma," J. Clin. Pathol. 46:149-153 (1993).
Hambelton and Mahon, "Drug actions on delayed-type hypersensitivity in rats with developing and established adjuvant arthritis," Agents and Actions 29:328-332 (1990).
Harris et al., "Breast Cancer (First of Three Parts)," New England J. of Medicine 327(5):319-328 (1992).
Heldin, "Structural and functional studies on platelet-derived growth factor," EMBO Journal 11:4251-4259 (1992).
Hoekstra et al., "Differential effects of steurosporine and tyrphostins on receptor tyrosine kinase autophosphorylation and peptide substrate phosphorylation," Experimental Therapeutics from 84th Annual Meeting of American Association for Cancer Research, vol. 34, #2455 (1993).
Honegger et al., "Point Mutation at the ATP Binding Site of EGF Receptor Abolishes Protein-Tyrosine Kinase Activity and Alters Cellular Routing," Cell 5:199-209 (1987).
Houck et al., "The Vascular Endothelial Growth Factor Family: Identification of a Fourth Molecular Species and Characterization of Alternative Splicing of RNA," Molecular Endocrinology 5:1806-1814 (1991).
Issidorides and Haddadin, "Benzofurazan Oxide. II. Reactions with Enolate Anions," J. Org. Chem. 31:4067-4068 (1966).
Ju et al., "Leflunomi

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