Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1998-12-29
2000-10-17
Gerstl, Robert
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
544301, C07D40312, A61K 31515
Patent
active
061332763
ABSTRACT:
Ligand inhibitors for increasing levels of free corticotropin-releasing factor (CRF) in the brain are disclosed. Such ligand inhibitors cause release of CRF from the CRF/CRF-bind protein complex. Administration of the ligand inhibitors provide improvement in learning and memory, result in decreased food intake and/or provide treatment for diseases associated with low levels of CRF in the brain, notably Alzheimer's disease.
REFERENCES:
patent: 3930006 (1975-12-01), Wiggins et al.
Ando et al. CA 86:107999, (Print out of CAS Online search), JP 51140926.
Ando et al., CA 84:166238), (Print out of CAS Online search), JP 51009122.
Mikitenko et al., CA 102:24575, (Print out of CAS Online search), Khim. Getrotsikl. Soedin. (1984), (8), 1126-8.
Wiley et al., J. Med. Chem., vol. 6, pp. 333-334, (1963).
Ahluwalia et al., "A novel one-pot facile synthesis of 1,3,-diaryl-6-ethoxycarbonyl-1,2,3,4-tetrahydro-4,7-dioxo-2-thioxo-7H-pyro na[2,3-d]pyrimidines," Indian Journal of Chemistry 35B: 1319-1321,1996.
Ahluwalia et al., "Synthesis of some new 1,3,-diaryl-5-(2,3-dihydrobenzothiazol-2-ylidene)-2-thiobarbituric acids," Indian Journal of Chemistry 33B: 1089-1090, 1994.
Ahluwalia et al., "Synthesis of some new substituted 1,3-diaryl-6-cyano-7-imino-7H-pyrano[2,3-d]pyrimidines," Indian Journal of Chemistry 32B: 1272-1274, 1993.
Clark-Lewis and Thompson, "5-Aminomethylene-1: 3-dimethylbarbituric Acids," Journal of the Chemical Society, No. III, pp. 2401-2408, 1959.
Eiden and Iwan, "Reaktionen von 1-Phenyl-1-cyan-2-aminoathen mit substituierten Acetaldehyden," Archiv der Pharmazie 304(8): 628-633, 1971. (+Chemical Abstract No. 75:151493).
Hirota et al., "Novel Intramolecular Rearrangement of 5-Carbamoyluracils into Barbituric Acids," Tetrahedron 46(10): 3431-3438, 1990.
Koyama and Kozuka, "Murexide Reaction of Caffeine with Hydrogen Peroxide and Hydrochloric Acid. II," J. Heterocyclic Chem. 27: 667-671, 1990.
Kumar et al., "Substituted Thiobarbituric Acids as Antiparkinsonian Agents," Indian Journal of Chemistry 22B: 955-958, 1983.
Mikitenko and Romanov, "Condensed heterocycles with a thiozole nucleus. 8. Thiazolo[3,4-a]pyrimido[5,4-e]pyrimidines," Chemical Abstracts Online, Abstract No. 102:24575, 1985. See Also Khim. Geterotsikl. Soedin (8): 126-1128, 1984.
Nightingale and Alexander, "Some Nitrogen Substituted Barbituric Acids and their Derivatives," Journal of the American Chemical Society 58: 794-796, 1936.
Nightingale and Taylor, "Phenyl Alkyl Nitrogen Substitution and Reactivity in the Barbituric Acid Series," Journal of the American Chemical Society 61: 1015-1017, 1939.
Pestov, D., "A New Synthetic Route to 5-Aminomethylene Derivatives of Barbituric Acids," Mendeleev Commun. (1): 14, 1994.
Ridi and Checchi, "Nuovi derivati antipirinici, iso-antipirinici, pirazolidinici," Annali di Chimica XLIII: 816-816, 1953. (+Chemical Abstract, col. 6234, Section d).
Sakellariou et al., "Preparation of a New Series, The 3-Ureidomethylenecoumarins By Condensation of 4-Hydroxycoumarin With Substituted Ureas," Synthetic Communications 20(22):3443-3451, 1990.
Schmidt et al., "Novel Barbituric Acid Derivatives, Uracil-Pyridinium Salts and Polycondensed Oxopyrimidines," Heterocycles 43(10): 2153-2167, 1996.
Tomkins et al., "BTS 71 412: In Vitro Profile of a Novel Pyrazlinone Immunosuppressant," Int. J. Immunopharmac. 17: 357-364, 1995.
Van Tinh et al., "Ring Closure Reactions of Cyclic 2-Arylaminomehtylene 1,3-diones," Journal Heterocyclic Chem. 33: 905-910, 1996.
Wiley et al. "Hydroxypyrimidine-5-carboxaldehyde Derivatives in Cancer Chemotherapy," Journal Medicinal Chemistry (3): 333-334, 1963.
Wipfler et al., "Zur Reaktivitat von C=N-Doppelbindungssystemen, XV Die Reaktion von Anilinomethylen-barbitursauren mit methylenaktiven Nitrilen," Z. Naturforsch 33b: 1016-1019, 1978. (+Chemical Abstract No. 90:186885).
Chalmers et al., "Corticotrophin-releasing factor receptors: from molecular biology to drug design," Trends in Pharmacological Science 17(4): 166-172, 1996.
Behan Dominic P.
Erickson Philip E.
Huang Charles Q.
Liu Zhengyu
McCarthy James R.
Gerstl Robert
Neurocrine Biosciences Inc.
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